NCT07310381Enrolling by invitation
Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement
Source: ClinicalTrials.gov · Last updated 2 Nov 2026
Brief summary (registry, in English)
The study will examine the autonomic, physiologic and neurophysiologic effects of implanted Vagus Nerve Stimulation (VNS) in treatment-resistant depression patients.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 12 (estimated)
- First submitted
- 19 Sept 2025
- Start date
- 17 Mar 2026
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Stanford University
- Diseases
- Depression
- NCT number
- NCT07310381
What you commit to
- Study type: Interventional
- Planned participants: 12
- From 17 Mar 2026 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Medication Contraindications
Other
- Participant does not speak or read English
- Any other clinical reasons deemed by the investigator of the study for which the participant would not be an appropriate candidate for the study.
- Contraindication to EEG
Who the study is looking for
- Participants must be at least 18 years old.
- Participants must be able to read, understand and have the capacity to provide written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization.
- Proficiency in English sufficient to complete questionnaire and follow instructions during fMRI assessments and iTBS interventions.
- Willingness to comply with all study procedures and the ability to communicate with study personnel about adverse events and other clinically important information
- Participant must be currently implanted with a VNS device for the clinical indication of Major Depressive Disorder (MDD)
- Clinical Indication of MDD as defined: Participant has a diagnosis of chronic (≥ 2 years) or ≥ 4 recurrent depressive episodes as defined by DSM-5 criteria documented using the MINI criteria and psychiatric medical record review.
- Access to ongoing psychiatric care before and after completion of the study.
- In good general health, as evidenced by medical history
- Agreement to adhere to Lifestyle Considerations throughout study duration.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine Coordinator of this site? Confirm its status | Stanford | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.