GENES AND AUTISM - Induced Pluripotent Stem Cells

Age

• For all participants
  • 1\) Refusal to have a blood test
  • 2\) Medical illness (including psychiatric disorder) not yet fully stabilised and making participation in the study impossible
  • 3\) Person subject to a mesure of lagal protection
  • 4\) Known serology : VIH+ or VBH+ or VCH+
  • As a reminder : exclusion criteria C07-33
  • 1\) For all participants : Severe Intelectual Deficiency (IQ,35 or developmental age \<18 months)
  • 2\) Controls : Neurological or psychiatric history other than mental retardation
  • o Psychiatric history, except for mental retardation, assessed using the DIGS (Diagnostic Interview for Genetic Studies, Nurnberger et al., 1994) for adults or the Kiddie-SADS (Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children, Orvaschel et al., 1982)
  • o History of epileptic episodes
  • o Immunosuppressive treatment or known immunoinflammatory disease
  • →As a reminder : exclusion criteria C16-89
  • 1\) Probands with Autism Spectrum Disorder
  • o Severe intellectual disability (IQ\<35 or developmental age \<18 months)
  • 2\) Controls (neurotypical development)
  • o Identified intellectual disorder or cognitive developmental disorder
  • Personal psychiatric history of schizophrenia, bipolar disorder, substance use disorders (except tobacco), recurrent depression (\>2 episodes, lifetime), severe unstabilized anxiety disorder
  • History of epilepsy episodes or severe neurological disease
  • 3\) Relatives of the TSA applicants or controls
  • Medical condition (psychiatric or somatic) not compatible with inclusion

• ● For all participants :
• 1\) Be Included in the "Genes and Autism" protocol (C07-33 or C16-89).
• 2\) Affiliated to the social insurance, Universal Health Coverage or any equivalent system.
  • →As a Reminder : C07-33 inclusion criteria
  • ● Participants with ASD.
• 1\) Autistic patients must meet the diagnostic criteria of DSM-IV \[American Psychiatric Association, 1994\] and the criteria of ADI-R (Autism Diagnostic Interview-Revised, Lord et al., 1994) and ADOS for autism.
  • ..Or.. Patients with Asperger's syndrome must meet the DSM-IV criteria as well as the ASDI criteria for Asperger's syndrome (Asperger Syndrome Diagnostic Interview, Gillberg et al., 2001) and the ADOS for autism spectrum disorders.
  • ..Or.. Patients with ASD must meet diagnostic criteria of DSM-IV and ADOS criteria for autism spectrum disorders
• 2\) Be at least 2 years old, with no upper age limit
• 3\) Somatic state compatible with blood test
  • ● Adult controls and adult relatives of controls
• 1\) Be between 18 and 65 years old
• 2\) Somatic and intellectual state compatible with blood test
  • ● Controls with mental retardation
• 1\) Minimum age of 2 yearsIQ \< 70Child controls
• 2\) Minimum age of 2 years
  • →As a Reminder : inclusion criteria C16-89
  • ● Probands with ASD
• 1\) Meet the diagnostic criteria for ASD of the of DSM-5 \[American Psychiatric Association, 2012\]. The diagnosis will be based on a consensus between the clinical expertise of expert clinicians, the scores of the Autism Diagnostic Interview-Revised (ADI-R) (Lord et al, 2003) and those of the Autism Diagnosis Observational Scale (ADOS-2) (Lord et al, 1994)
• 2\) Be at least 24 months old with no upper age limit
• 3\) Somatic state compatible with a blood test
• 4\) Affiliation to the Social Insurance
• 5\) Signature of informed consent by the applicant or by the holders of parental authority if the subject is a minor or by the guardian if the subject is under guardianship
  • ● Controls wihout ASD
• 1\) At least 24 months old
• 2\) Somatic and Intellectual state compatible with a blood test
• 3\) Affiliation in the Social Insurance
• 4\) Signature of informed consent by the subject or by holders of parental authority if the subject is a minor, or by the guardian if the subject is under guardianship
  • ● Relatives of the probands with ASD or of controls without ASD
• 1\) At least 24 months old
• 2\) Somatic and intellectual state compatible with blood test
• 3\) Affiliation to the Social Insurance
• 4\) Signature of informed consent by the subject or by the holders of parental authority if the subject is a minor or by the guardian if the subject is under guardianship