NCT07312045Recruiting
HALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 in Periodontal Disease and Healing After Non-Surgical Therapy
The Relationship of HALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 Levels With Periodontal Disease and Healing After Non-Surgical Periodontal Therapy
Source: ClinicalTrials.gov · Last updated 31 Dec 2025
Brief summary (registry, in English)
This observational clinical study aims to investigate the relationship between the HALP score (Hemoglobin × Albumin × Lymphocyte / Platelet), several blood-based inflammatory indices (including NLR, PLR, LMR, and SII), and salivary MMP-8 levels in individuals with periodontal health, gingivitis, and stage III/IV periodontitis. The study also evaluates how these biomarkers relate to healing following non-surgical periodontal therapy. A total of 180 participants aged 18-65 years will be included: 50 healthy individuals, 50 patients with gingivitis, and 80 patients with stage III/IV periodontitis. All participants will undergo periodontal clinical examination and provide blood and saliva samples at baseline. Individuals in the gingivitis and periodontitis groups will receive standard non-surgical periodontal treatment (full-mouth debridement) and will return for a 3-month follow-up visit, where periodontal measurements will be repeated. In the periodontitis group, an additional blood sample will be collected at the 3-month follow-up visit. The primary objective is to determine whether baseline HALP score, systemic inflammatory indices, and salivary MMP-8 levels differ between participants who show good versus poor healing after treatment. Secondary objective include comparing biomarker levels across periodontal status groups. The findings may contribute to early prediction of treatment response and personalized periodontal care.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 180 (estimated)
- First submitted
- 27 Nov 2025
- Start date
- 25 Nov 2025
- Primary completion date
- 25 Nov 2026
- Lead sponsor
- Ömer Faruk Okumuş
- NCT number
- NCT07312045
What you commit to
- Study type: Observational
- Planned participants: 180
- From 25 Nov 2025 to the primary completion date, 25 Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of antibiotics, anti-inflammatory medications, or immunosuppressive drugs within the last 3 months
Other illness
- Systemic diseases influencing periodontal inflammation (e.g., diabetes, autoimmune disorders)
- History of periodontal surgery in the last 6 months
- Any condition that may interfere with study participation or data reliability
Other
- Current pregnancy or lactation
- Smokers or individuals using tobacco products
- Presence of fewer than 20 natural teeth
Who the study is looking for
- Adults aged 18-65 years
- Ability to provide informed consent
- No systemic diseases or conditions affecting periodontal status
- For Healthy Group: Probing depth ≤3 mm, no attachment loss, no radiographic bone loss
- For Gingivitis Group: Gingival inflammation and bleeding on probing without attachment loss or bone loss
- For Periodontitis Group: Stage III or stage IV periodontitis according to 2018 classification
- No periodontal treatment within the past 6 months
- Willingness to attend follow-up visits
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Erzincan Binali Yıldırım University Faculty of Dentistry Coordinator of this site? Confirm its status | Merkez | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.