NCT07312266Recruiting
Questioning the Epidemiology of Asymptomatic TB
Source: ClinicalTrials.gov · Last updated 31 Dec 2025
Brief summary (registry, in English)
Tuberculosis (TB) remains one of the world's leading causes of morbidity and mortality. Current TB control strategies focus largely on the binary paradigm of TB, which tackle Mtb infection and the symptomatic stages of the disease as the major drivers of the TB epidemic. However, prevalence surveys have shown that about 50% of cases in which Mycobacterium tuberculosis is isolated from sputum but do not report having symptoms. Therefore, asymptomatic TB may play an important role in TB transmission. However, no field study has demonstrated direct transmission from a subclinical TB case to a confirmed secondary case. TB-QUEST is an ERC-funded epidemiological field study that aims to provide direct evidence of effective transmission from asymptomatic TB cases to their close contacts using advanced genomic methods, and to better characterize the asymptomatic stage of TB within the natural history of disease.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 6770 (estimated)
- First submitted
- 17 Dec 2025
- Start date
- 11 Aug 2025
- Primary completion date
- Nov 2028
- Lead sponsor
- Barcelona Institute for Global Health
- Diseases
- Tuberculosis, HIV
- NCT number
- NCT07312266
What you commit to
- Study type: Observational
- Planned participants: 6770
- From 11 Aug 2025 to the primary completion date, Nov 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently taking anti-tuberculosis treatment or preventive TB treatment
Other illness
- History of TB treatment in the last 12 months
Other
- Pregnant women
- Refusal to provide consent for study procedures
- Contra-indication to any sampling procedure required by the study
- Study 3 will utilize additional inclusion criteria:
- Plans to migrate in the next 12 months
- Pregnant women
- Contacts with co-prevalent TB identified at baseline
Who the study is looking for
- 18 years of age or older
- Documented HIV infection
- Presenting at a health facility for routine HIV care
- On ART for less than 6 months
- No evidence of viral suppression
- Documented CD4 count \>350 copies/ul
- TB-suggestive x-ray
- Verified absence of fever and cough, as ascertained through the symptom trackers
- Contacts:
Criteria the registry did not label
- Index cases:
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centro de Investigação em Saúde de Manhiça (CISM) Coordinator of this site? Confirm its status | Manhiça | Mozambique | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.