NCT07312682Active, not recruiting
Application of 4DCT-Based Pulmonary Ventilation Imaging in Lung Cancer Radiotherapy
Clinical Study on 4DCT-Based Pulmonary Ventilation Imaging for Functional Lung Avoidance in Radiotherapy of Lung Cancer
Source: ClinicalTrials.gov · Last updated 9 Feb 2026
Brief summary (registry, in English)
This retrospective single-center study investigates whether four-dimensional CT (4DCT)-based lung ventilation imaging can guide functional lung avoidance radiotherapy (FLAR) for patients with primary lung cancer. Ventilation maps generated from planning 4DCT are used to identify well-ventilated lung regions, enabling paired comparison between functional lung avoidance radiotherapy plans and conventional anatomic radiotherapy plans. The study aims to assess whether incorporating functional lung information into radiotherapy planning can reduce radiation exposure to well-ventilated lung while maintaining adequate tumor coverage, and to explore its relationship with radiation-induced lung injury. All analyses are based on existing clinical imaging, treatment planning data, and follow-up records. No additional interventions, imaging, or procedures are performed as part of this study.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 202 (actual)
- First submitted
- 9 Sept 2025
- Start date
- 9 Dec 2024
- Primary completion date
- 9 Sept 2025
- Lead sponsor
- The Second Affiliated Hospital of Chongqing Medical University
- Diseases
- Lung cancer
- NCT number
- NCT07312682
What you commit to
- Study type: Observational
- Participants enrolled: 202
- From 9 Dec 2024 to the primary completion date, 9 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Radiotherapy interrupted or incomplete for any reason.
- Prior lung surgery or local therapies (e.g., ablation) that may affect evaluation of radiation-induced lung injury.
- Missing follow-up data, making assessment of radiation-induced lung injury or long-term lung function changes impossible.
Other illness
- Severe underlying lung diseases (e.g., extensive emphysema, pulmonary fibrosis, active tuberculosis) that may confound treatment outcomes or toxicity assessment.
- Presence of other untreated primary malignancies during the study period.
Other
- Incomplete or poor-quality imaging data preventing accurate ventilation/perfusion map generation.
Who the study is looking for
- Histologically confirmed primary lung cancer (adenocarcinoma, squamous cell carcinoma, or small-cell carcinoma) treated with thoracic radiotherapy.
- High-quality 4DCT scans performed before radiotherapy, enabling generation of ventilation or perfusion maps.
- Radiotherapy plans designed using IMRT.
- Availability of both functional lung avoidance plans and conventional anatomical radiotherapy plans for paired analysis.
- Complete treatment and follow-up records, including radiation-induced lung injury (e.g., radiation pneumonitis) and pulmonary function tests.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cancer Center, Second Affiliated Hospital of Chongqing Medical University Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.