NCT07315412Not yet recruiting
Chewing Gum Flavors to Reduce Postoperative Nausea and Vomiting After PIPAC
Comparative Effectiveness of Ginger-Mint and Cinnamon-Flavored Gum in Preventing Nausea and Vomiting Following Pressurized Intraperitoneal Aerosol Chemotherapy
Source: ClinicalTrials.gov · Last updated 2 Jan 2026
Brief summary (registry, in English)
This randomized controlled clinical trial aims to evaluate the effectiveness of chewing gum with different natural flavors in reducing postoperative nausea and vomiting (PONV) following Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). Adult patients undergoing PIPAC will be randomly assigned to one of three groups: (1) ginger-mint flavored gum, (2) cinnamon flavored gum, or (3) control group with standard postoperative care only. Participants in the intervention arms will chew one piece of gum for 15 minutes in the post-anesthesia care unit (PACU). Nausea intensity (Numeric Rating Scale, 0-10) and the presence of vomiting or retching will be assessed at baseline and every 15 minutes for 2 hours. The study hypothesizes that ginger-mint and cinnamon flavored chewing gums, both plant-based and certified vegan, will be effective, non-pharmacological, and safe methods to reduce nausea and vomiting after PIPAC. This research may contribute to enhanced postoperative comfort and faster recovery by supporting the principles of Enhanced Recovery After Surgery (ERAS).
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 75 (estimated)
- First submitted
- 4 Dec 2025
- Start date
- 10 Dec 2025
- Primary completion date
- 30 Jan 2026
- Lead sponsor
- Fenerbahce University
- Diseases
- Colorectal cancer
- NCT number
- NCT07315412
What you commit to
- Study type: Interventional
- Planned participants: 75
- From 10 Dec 2025 to the primary completion date, 30 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Need for rescue antiemetic medication within the first 2 postoperative hours.
- Anatomical or functional limitation preventing chewing (e.g., full dentures, jaw restriction, oral surgery).
- Active chemotherapy, radiotherapy, or immunosuppressive therapy affecting gastrointestinal function.
Other illness
- History of psychiatric disorder, neurological disease, or cognitive impairment affecting participation.
Other
- Postoperative complications requiring intensive care or reoperation.
- Known phenylketonuria or metabolic intolerance to chewing gum ingredients.
Who the study is looking for
- Adults aged 18 years or older undergoing Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC).
- Able to communicate, understand study instructions, and provide written informed consent.
- No known allergy or intolerance to ginger, mint, or cinnamon.
- Able and willing to chew gum for 15 minutes.
- Apfel risk score ≥3 for postoperative nausea and vomiting.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Health Sciences, Umraniye Training and Research Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.