NCT07316452Recruiting
Risk Prediction of Disease Progression in Early-Onset Coronary Atherosclerosis
Source: ClinicalTrials.gov · Last updated 5 Jan 2026
Brief summary (registry, in English)
This study is part of a nationwide research project in China that aims to better understand how coronary artery disease develops and progresses in young adults. The study will enroll approximately 10,000 participants aged 45 years or younger who undergo coronary CT scans at multiple hospitals across China. Information collected at enrollment includes basic health information, cardiovascular risk factors, blood test results, medication use, lifestyle habits, and, for some participants, genetic data. Participants will undergo follow-up coronary CT scans after several years to evaluate changes in coronary artery plaque and disease progression. By analyzing these clinical and imaging data, the study aims to identify factors associated with disease progression and to develop prediction models that may help estimate an individual's future risk of coronary plaque progression and cardiovascular events. The results of this study may contribute to improved risk assessment and early prevention strategies for coronary artery disease in young populations.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 10000 (estimated)
- First submitted
- 19 Dec 2025
- Start date
- 1 Jan 2025
- Primary completion date
- 1 Sept 2027
- Lead sponsor
- Fu Wai Hospital, Beijing, China
- Diseases
- Coronary artery disease
- NCT number
- NCT07316452
What you commit to
- Study type: Observational
- Planned participants: 10000
- From 1 Jan 2025 to the primary completion date, 1 Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of coronary revascularization, including percutaneous coronary intervention or coronary artery bypass grafting.
- Presence of severe systemic disease with limited life expectancy that may interfere with study follow-up.
Other
- Inability or unwillingness to complete follow-up assessments.
- Inability to provide written informed consent.
- Poor-quality coronary computed tomography images that are inadequate for reliable plaque assessment.
- Pregnant or breastfeeding women.
- Participation in another clinical study that may interfere with the outcomes of this study.
Who the study is looking for
- Age between 18 and 45 years at the time of enrollment.
- Presence of symptoms suggestive of coronary artery disease and completion of coronary computed tomography (CT) examination.
- Ability and willingness to provide written informed consent and to participate in follow-up assessments.
Age in the registry: 18 years to 45 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fuwai Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.