NCT07319949Not yet recruiting
Evaluating the Predictive Capability of Transcriptomic Profiling for Identifying the Primary Site of Metastatic Tumors
Evaluative Study on Predicting the Primary Site of Metastatic Tumors Using Transcriptomic Profiling for Tumor Tissue Origin Identification
Source: ClinicalTrials.gov · Last updated 6 Jan 2026
Brief summary (registry, in English)
This study will enroll patients with metastatic malignancies. Tumor samples (fresh or formalin-fixed paraffin-embedded tissue specimens) will undergo RNA extraction and next-generation sequencing (RNA-seq). Once the raw data is obtained, the system will analyze the transcriptomic feature values (cancer-specific RNA transcripts and tissue-specific RNA transcripts) expressed in the tumor tissue samples to further predict tissue origin using a machine learning model. The output includes probabilities and confidence intervals for tissue origin.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 30 (estimated)
- First submitted
- 8 Dec 2025
- Start date
- Jan 2026
- Primary completion date
- Oct 2026
- Lead sponsor
- Fudan University
- Diseases
- Childhood cancers
- NCT number
- NCT07319949
What you commit to
- Study type: Observational
- Planned participants: 30
- From Jan 2026 to the primary completion date, Oct 2026
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- 1\. The investigator deems the patient unable to provide informed consent.
Who the study is looking for
- Clinically confirmed diagnosis of malignant tumor with metastasis;
- Metastatic lesions confirmed as malignant by histopathology;
- Sufficient surgical resection or biopsy specimens retained to meet the requirements for next-generation sequencing;
- The participant (or their legal representative/guardian) has signed the informed consent form, confirming full understanding of the study's purpose and procedures, and voluntarily agrees to participate.
Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.