NCT07320846Recruiting
The Effect of Exercise Training on lncRNA Expression in Rheumatoid Arthritis
Investigation of the Effects of Standard Rehabilitation Program and Inspiratory Muscle Training on lncRNA HOTAIR Expression in Patients With Rheumatoid Arthritis
Source: ClinicalTrials.gov · Last updated 6 Jan 2026
Brief summary (registry, in English)
The goal of this observational study is to examine the effects of traditional respiratory rehabilitation and respiratory muscle strengthening training added to this program at the genetic level in in patients with rheumatoid arthritis-associated interstitial lung disease. The main questions it aims to answer are: * Does respiratory muscle strengthening exercise added to respiratory rehabilitation in patients with rheumatoid arthritis-associated interstitial lung disease have additional benefits on rehabilitation outcome measures such as exercise capacity, shortness of breath, and muscle strength? * Does the gain obtained with respiratory muscle strengthening iin patients with rheumatoid arthritis-associated interstitial lung disease increase the quality of life of patients and have a positive effect on their psychological state? * Does respiratory rehabilitation applied to iin patients with rheumatoid arthritis-associated interstitial lung disease have an effect on genetic changes? * Does respiratory muscle strengthening training applied in addition to respiratory rehabilitation in patients with rheumatoid arthritis-associated interstitial lung disease have an effect on genetic changes? * Participants will be included in two different respiratory rehabilitation programs with and without respiratory muscle training, and pre- and post- treatment rehabilitation criteria and genetic changes will be compared.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 39 (estimated)
- First submitted
- 3 Dec 2025
- Start date
- 18 May 2024
- Primary completion date
- 1 Oct 2025
- Lead sponsor
- Saglik Bilimleri Universitesi
- Diseases
- Rheumatoid arthritis
- NCT number
- NCT07320846
What you commit to
- Study type: Interventional
- Planned participants: 39
- From 18 May 2024 to the primary completion date, 1 Oct 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncontrolled diabetes or heart disease
- Patients with severe organ failure
- Recent acute coronary syndrome
- Presence of active infection
Other
- Having orthopedic deformities that may affect the treatment program
- Pregnancy
- Participation in a rehabilitation program within the last 6 months
- Body Mass Index (BMI) \> 30
Who the study is looking for
- Diagnosed with RA according to the ACR/EULAR 2010 classification criteria
- Duration of diagnosis greater than 2 years
- Disease activity with a DAS28 score below 5.1
- Voluntary participation in the study
- Presence of lung involvement
Age in the registry: 18 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Health Sciences Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.