NCT07321886RecruitingPhase 3
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes ( ENLIGHTEN-1).
J3R-MC-YDAG - A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, Without Type 2 Diabetes
Source: EU CTIS (euclinicaltrials.eu) · Last updated 17 Sept 2026
Brief summary (registry, in English)
To demonstrate that eloralintide is superior to placebo for change in body weight.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 254 (estimated)
- First submitted
- 24 Nov 2025
- Start date
- 13 Apr 2026
- Lead sponsor
- Eli Lilly & Co.
- Diseases
- Obesity, Type 2 diabetes
- EU CT number
- 2025-523657-34-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 254
- 25 sites in 3 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have had or are planning to have surgery, an endoscopic procedure, and/or device-based therapy for weight loss (with exceptions)
- Have had a serious heart condition within 90 days prior to screening
- Have taken medications or alternative remedies for weight loss within 90 days of screening
Other illness
- Have type 1 diabetes or type 2 diabetes
Who the study is looking for
- Have obesity or overweight
- If overweight, must also have one of the following: high blood pressure, high cholesterol, obstructive sleep apnea or heart disease
- Have a stable body weight (<5% body weight change) for 90 days prior to screening
- Have at least one self-report of an unsuccessful dietary effort to lose weight
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (25)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Anima Coordinator of this site? Confirm its status | Alken | Belgium | Recruiting |
| JESSA Ziekenhuis Coordinator of this site? Confirm its status | Hasselt | Belgium | Recruiting |
| Kormont Coordinator of this site? Confirm its status | Kluisbergen | Belgium | Recruiting |
| Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden Coordinator of this site? Confirm its status | Dresden | Germany | Recruiting |
| MVZ Hausaerzte Grossenbaum GmbH Coordinator of this site? Confirm its status | Duisburg | Germany | Recruiting |
| InnoDiab Forschung Gmbh Coordinator of this site? Confirm its status | Essen | Germany | Recruiting |
| Medizentrum Essen Borbeck Coordinator of this site? Confirm its status | Essen | Germany | Recruiting |
| Diabetes Zentrum Wilhelmsburg GbR Coordinator of this site? Confirm its status | Hamburg | Germany | Recruiting |
| Diabeteszentrum Hamburg West Coordinator of this site? Confirm its status | Hamburg | Germany | Recruiting |
| Zentrum fur klinische Forschung - Köln Coordinator of this site? Confirm its status | Köln | Germany | Recruiting |
| Ambenet GmbH Das Ambulante Behandlungsnetz Coordinator of this site? Confirm its status | Leipzig | Germany | Recruiting |
| Diabetologische Schwerpunktpraxis Dr. Staudenmeyer & Dr. Schiwietz Coordinator of this site? Confirm its status | Lingen | Germany | Recruiting |
| BAG Drs. Med. Quist PartG Coordinator of this site? Confirm its status | Mainz | Germany | Recruiting |
| CRS Clinical Research Services Management GmbH Coordinator of this site? Confirm its status | Mannheim | Germany | Recruiting |
| R.E.D. Institut fuer medizinische Studien und Fortbildung GmbH Coordinator of this site? Confirm its status | Oldenburg in Holstein | Germany | Recruiting |
| Praxis Sauter & Vorbach Coordinator of this site? Confirm its status | Wangen im Allgäu | Germany | Recruiting |
| NZOZ ZDROWIE OSTEO-MEDIC Coordinator of this site? Confirm its status | Bialystok | Poland | Recruiting |
| Legeartis Poradnie Specjalistyczne Sp. z o.o. Coordinator of this site? Confirm its status | Bialystok | Poland | Recruiting |
| Medyczne Centrum Diabetologiczno-Endokrynologiczno-Metaboliczne Diab-Endo-Met Sp. z o.o. Coordinator of this site? Confirm its status | Cracow | Poland | Recruiting |
| Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A. Coordinator of this site? Confirm its status | Lodz | Poland | Recruiting |
| EKAMED sp. z o.o. Coordinator of this site? Confirm its status | Lublin | Poland | Recruiting |
| Terpa Sp. z o.o. Sp. k. Coordinator of this site? Confirm its status | Lublin | Poland | Recruiting |
| Centrum Zdrowia Metabolicznego Pawel Bogdanski Coordinator of this site? Confirm its status | Poznan | Poland | Recruiting |
| PRACOWNIA BADAŃ KLINICZNYCH SALUS Coordinator of this site? Confirm its status | Wrocław | Poland | Recruiting |
| Samodzielny Publiczny Szpital Kliniczny Nr 1 Im.Prof.Stanislawa Szyszko Slaskiego Uniwersytetu Medycznego W Katowicach Coordinator of this site? Confirm its status | Zabrze | Poland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.