NCT07323914RecruitingPhase 3
Clinical Analgesic Management in Dementia
A Clinical Study on the Efficacy of Analgesic Treatments for Chronic Pain in Patients With Dementia
Source: ClinicalTrials.gov · Last updated 7 Jan 2026
Brief summary (registry, in English)
This study is designed to assess the efficacy and safety of oxycodone in managing moderate to severe pain in patients with Alzheimer's disease. The trial will be conducted at Xuanwu Hospital, Capital Medical University, and will enroll 10 eligible participants. Participants will receive oxycodone/acetaminophen (5 mg/325 mg) once daily for 12 weeks. The treatment will follow international guidelines, with dosages adjusted based on the patient's baseline pain levels and individual needs. Dosages will be adjusted based on baseline pain levels and patient needs, following international guidelines. Efficacy and adverse events will be assessed at baseline, week 6, week 12, and at a 12-week post-treatment follow-up. The primary outcome is change in VAS pain scores; secondary outcomes include PAINAD, SF-36, functional ability, and safety profiles.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 23 Dec 2025
- Start date
- 1 Mar 2025
- Primary completion date
- 1 Jan 2027
- Lead sponsor
- Xuanwu Hospital, Beijing
- Diseases
- Alzheimer disease
- NCT number
- NCT07323914
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 10
- From 1 Mar 2025 to the primary completion date, 1 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Alcohol dependence, substance abuse, or other drug addiction or addictive tendency.
Other illness
- History of transient ischemic attack (TIA), stroke, or seizure within the past 12 months.
- Presence of any psychiatric diagnosis or symptoms that may interfere with study participation (e.g., hallucinations, major depression, or delusions).
- Known allergy to opioid analgesics.
- Severe visual or hearing impairment.
- Current participation in another study related to the treatment of Alzheimer's disease.
- Any other uncontrolled or inadequately treated medical condition (e.g., cardiac, respiratory, gastrointestinal, hepatic, or renal disease), or any condition judged by the investigator to compromise participant safety or interfere with study assessments.
Other
- Any other reason deemed by the investigator to preclude participation in the study.
Who the study is looking for
- Male or female, aged 50 to 90 years at the time of enrollment.
- Meets the NIA-AA core clinical diagnostic criteria for probable Alzheimer's disease.
- Clinical Dementia Rating - Global Score (CDR-GS) between 0.5 and 2.0, inclusive, and Clinical Dementia Rating - Memory Box (CDR-MB) score ≥ 0.5.
- Diagnosed with chronic pain within 6 months prior to enrollment and considered appropriate for opioid therapy.
- Presence and severity of pain confirmed using PAINAD, MOBID-2, or comparable scales.
- Educational attainment: at least 4-6 years of formal education, or not illiterate.
- If currently receiving psychotropic or cognitive-enhancing medications, the dosage must have been stable for at least 3 months prior to study entry and remain unchanged during the study. Unless otherwise specified, all other permitted concomitant medications (non-AD related) must be stably administered for at least 4 weeks prior to baseline.
- Has a reliable caregiver/companion who can assist with study participation, defined as a person who can support the participant throughout the study and spend at least 8 hours per week with the participant.
- Willing and able to participate in this clinical trial, to maintain the assigned intervention during the study period, and has signed the informed consent form.
Age in the registry: 50 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Xuanwu Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.