NCT07326930Recruiting
Tracjectories and Predictors of Chemotherapy Induced Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia
Tracjectories and Predictors of Chemotherapy Induced Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia: A Perspective Longitudinal Study
Source: ClinicalTrials.gov · Last updated 8 Jan 2026
Brief summary (registry, in English)
The goal of this study is to explore the trajectory patterns of chemotherapy induced peripheral neuropathy over the course of chemotherapy and identify predictors of distinct trajectories in children with acute lymphoblastic leukemia. A perspective longitudinal study design is utilized. Chemotherapy induced peripheral neuropathy was assessed at one week after the first use of Vincristine (VCR) (T1), one week after the second use of VCR (T2), one week after the third use of VCR (T3), one week after the fourth use of VCR (T4), two weeks after T4 (T5), two weeks after T5 (T6), two weeks after T5 (T7). Patients' demographic and clinical characteristics, physical symptoms, nutrition status, psychological distress, sleep quality, physical activity, perceived social support and coping strategy are obtained at baseline.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 173 (estimated)
- First submitted
- 24 Dec 2025
- Start date
- 2 Jun 2025
- Primary completion date
- 7 Jan 2026
- Lead sponsor
- The Hong Kong Polytechnic University
- NCT number
- NCT07326930
What you commit to
- Study type: Observational
- Planned participants: 173
- From 2 Jun 2025 to the primary completion date, 7 Jan 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- participating other experimental trials, such as electrical stimulation, exercise therapy may improve CIPN symptoms.
- had multiple treatment like radiotherapy.
Other illness
- with severe complications, including but not limited to significant heart, brain, or lung function failure.
- had peripheral neuropathy symptoms caused by other diseases like genetic diseases, spinal cord injury.
- had neuromuscular diseases (e.g., traumatic brain injury and cerebral palsy).
- had central nervous system cancer or secondary cancer.
Who the study is looking for
- diagnosed with acute lymphoblastic leukemia
- aged from 8 to 17 years
- will receive vincristine according the Chinese Children's Cancer Group Acute Lymphoblastic Leukemia-2020 Project (CCCG-ALL-2020)
- conscious with sufficient cognitive abilities to understand and express their physical state and psychological feelings accurately
- written informed assent is obtained from the children and their parents for their participation in the study
Age in the registry: 8 years to 17 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shanghai Children's Medical Center Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
| Shenzhen Children's Hospital Coordinator of this site? Confirm its status | Shenzhen | China | Recruiting |
| The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital Coordinator of this site? Confirm its status | Zhengzhou | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.