NCT07327086Completed
Serum Chromium, Nickel, and Magnesium in Type 2 Diabetic Periodontitis
Evaluation of Serum Chromium, Nickel, and Magnesium Levels in Patients With Type 2 Diabetes Mellitus and Periodontitis: A Cross-Sectional Study
Source: ClinicalTrials.gov · Last updated 8 Jan 2026
Brief summary (registry, in English)
Periodontitis is a chronic immunoinflammatory disease that has been increasingly associated with systemic conditions, particularly type 2 diabetes mellitus (T2DM). Trace elements such as chromium (Cr), magnesium (Mg), and nickel (Ni) play important roles in metabolic regulation, insulin signaling, inflammatory responses, and tissue integrity. Alterations in the serum levels of these elements have been reported in T2DM; however, their relationship with periodontal status remains poorly understood. This cross-sectional observational study aims to evaluate serum Cr, Mg, and Ni levels in individuals with T2DM and chronic periodontitis and to investigate their potential associations with periodontal clinical parameters.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 74 (actual)
- First submitted
- 24 Dec 2025
- Start date
- 1 Jul 2025
- Primary completion date
- 30 Oct 2025
- Lead sponsor
- Kahramanmaras Sutcu Imam University
- Diseases
- Type 2 diabetes
- NCT number
- NCT07327086
What you commit to
- Study type: Observational
- Participants enrolled: 74
- From 1 Jul 2025 to the primary completion date, 30 Oct 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of systemic diseases other than type 2 diabetes mellitus (e.g., renal or hepatic failure, cardiovascular disease, organ transplantation, or current or previous cancer treatment)
- History of non-surgical periodontal treatment within the last 6 months or periodontal surgery within the last 12 months
Lab values
- Use of antibiotics, non-steroidal anti-inflammatory drugs, corticosteroids, immunosuppressive drugs, calcium channel blockers, beta blockers, oral contraceptives, or anticoagulants within the last 3 months
Other
- Pregnancy or lactation
- Body mass index (BMI) ≥ 30 kg/m²
- Current smoking or alcohol consumption
- Use of vitamin, mineral, or antioxidant supplements within the last 3 months
Who the study is looking for
- Adults aged ≥18 years
- Having at least 20 natural teeth, excluding third molars
- Diagnosed with type 2 diabetes mellitus or systemically healthy, according to group allocation
- Willingness to participate in the study and provision of written informed consent
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kahramanmaraş Sütçü imam University Coordinator of this site? Confirm its status | Kahramanmaraş | Turkey (Türkiye) | Unknown status |
Related publications
- Evaluation of serum chromium, nickel, and magnesium levels in patients with type 2 diabetes mellitus and periodontitis: A cross-sectional study.Clin Oral Investig · 2026 · PMID 42507181
This page is information, not medical advice. Discuss any trial with your doctor.