NCT07328386Recruiting
Effect of Cervical Lymphaticovenous and Lymph Node-to-Vein Anastomosis in Patients With Intracranial Lymphatic Circulation Disorder
Effect of Cervical Lymphaticovenous Anastomosis and Cervical Lymph Node to Vein Anastomosis for the Patient With Intracranial Lymphatic Circulation Disorder
Source: ClinicalTrials.gov · Last updated 9 Jan 2026
Brief summary (registry, in English)
This study is a single-center, prospective clinical trial designed to evaluate the therapeutic effects of lymphaticovenular anastomosis (LVA) and lymph node-venous anastomosis (LNVA) in patients with intracranial lymphatic circulation disorders. Following voluntary written informed consent, screening assessments will be performed in accordance with the clinical trial protocol. Eligibility will be determined based on the predefined inclusion and exclusion criteria, and eligible subjects will be enrolled in the study. Enrolled participants will undergo cognitive function assessments at baseline (pre-surgery) and at 1, 3, 6, 9, 12, 18, and 24 months postoperatively for follow-up. Cognitive evaluations will not be additionally performed for research purposes but will be conducted in accordance with the existing clinical care schedule and standard treatment guidelines.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 114 (estimated)
- First submitted
- 25 Nov 2025
- Start date
- Feb 2025
- Primary completion date
- Dec 2026
- Lead sponsor
- Hong Joonpio
- Diseases
- Alzheimer disease
- NCT number
- NCT07328386
What you commit to
- Study type: Interventional
- Planned participants: 114
- From Feb 2025 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Unable to undergo follow-up evaluation for at least 12 months after surgery.
- History of previous neck surgery.
Other illness
- Diagnosed with vascular dementia.
- Presence of structural brain disease other than intracranial lymphatic circulation disorder.
- Known hypersensitivity to indocyanine green (ICG).
- Uncontrolled systemic medical conditions such as severe cardiopulmonary, renal, hepatic, or endocrine disorders.
- Refusal to participate or failure to provide informed consent.
Other
- Determined by the principal investigator to be unsuitable for participation due to any other clinical reason.
Who the study is looking for
- Patients aged 19 years or older who are diagnosed with intracranial lymphatic circulation disorder based on neurological evaluation.
- Global Deterioration Scale (GDS) score between 3 and 5 at screening.
- Diagnosis of Alzheimer's disease confirmed by amyloid PET-CT or CSF amyloid testing, showing amyloid accumulation associated with lymphatic circulation disorder.
- Able to provide written informed consent to participate in the study voluntarily.
Age in the registry: 19 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Asan Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.