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NCT07329127Completed

The Prevalence of Osmophobia in Migraine and Tension-Type Headache Patients and Its Association With Migraine Symptoms Over a Period of 6 Months

Osmophobia Is Likely the Best Phenotypic Indicator of Migraine: A Prospective, Non-Interventional, 6-Month Longitudinal Study

Source: ClinicalTrials.gov · Last updated 9 Jan 2026

Brief summary (registry, in English)

The goal of this observational study is to learn about the frequency and diagnostic value of osmophobia, which is a sensitivity to smell, in people with migraine compared to those with tension-type headache. The main question it aims to answer is: Does osmophobia reliably indicate a migraine rather than a tension-type headache? Participants diagnosed with migraine or tension-type headache at the Headache Outpatient Department of Aeginition Hospital of Athens will record their headaches and any sensitivity to smells using a headache diary and a special osmophobia calendar over a period of six months. They will also complete questionnaires about migraine burden and related health conditions.

Status (registry)
Completed
Study type
Observational
Enrollment
210 (actual)
First submitted
4 Dec 2025
Start date
8 Jan 2024
Primary completion date
30 Dec 2024
Lead sponsor
National and Kapodistrian University of Athens
Diseases
Migraine
NCT number
NCT07329127

What you commit to

  • Study type: Observational
  • Participants enrolled: 210
  • From 8 Jan 2024 to the primary completion date, 30 Dec 2024
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • Patients with primary or secondary anosmia
  • Inability to obtain written consent

Who the study is looking for

  • Patients with a diagnosis of migraine or tension-type headache (ICHD-3)
  • Age \>16 years
  • Patients with or without medication overuse headache
  • Patients with or without prophylaxis
  • Patients with or without comorbidity with mood disorders
  • Patients will have signed informed consent to participate in the study

Age in the registry: 16 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Aeginition Hospital of Athens
Coordinator of this site? Confirm its status
AthensGreeceUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.