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NCT07330141Completed

Optimizing Recovery in Pediatric ALL Survivors: A Training Comparison

Optimizing Post-Chemotherapy Recovery: A Head-to-Head Trial of Graded vs. Constant-Load Aerobic Exercise in Pediatric ALL Survivors

Source: ClinicalTrials.gov · Last updated 26 Jun 2026

Brief summary (registry, in English)

This study compared the effects of constant-load aerobic exercise (CL-AEx) and graded aerobic exercise (G-AEx) on cardiopulmonary fitness and functional capacity in pediatric survivors of acute lymphoblastic leukemia (ALL). A cohort of 72 pediatric ALL survivors was randomly assigned to one of three groups: a CL-AEx group (n=24), a G-AEx group (n=24), or a control group (n=24). All groups participated in a structured exercise regimen. The CL-AEx group performed additional moderate-intensity aerobic training at a fixed load, while the G-AEx group performed additional aerobic training with progressive increases in intensity and duration. The control group performed the structured exercise regimen only. Interventions were administered three times per week for 12 consecutive weeks. Cardiopulmonary fitness and functional capacity were assessed in all three groups at baseline and following the completion of the 12-week intervention.

Status (registry)
Completed
Study type
Interventional
Enrollment
72 (actual)
First submitted
29 Dec 2025
Start date
3 Dec 2023
Primary completion date
31 Oct 2024
Lead sponsor
Cairo University
NCT number
NCT07330141

What you commit to

  • Study type: Interventional
  • Participants enrolled: 72
  • From 3 Dec 2023 to the primary completion date, 31 Oct 2024
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Secondary cancers
  • Neuro-musculoskeletal conditions are likely to impede the training.

Other

  • Neurodegenerative impairments affecting memory, attention, or executive functioning

Who the study is looking for

  • Age between 10 and 18 years old
  • Complete maintenance chemotherapy
  • Normal cardiac structure and function
  • Absence of lower limb deformities
  • Not engaging in regular exercise regimens

Age in the registry: 10 years to 18 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Ragab K. Elnaggar
Coordinator of this site? Confirm its status
Al KharjSaudi ArabiaUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.