NCT07331350Completed
Exercise Balance Program for Fall Prevention in Multiple Sclerosis
Effects of an Otago-Based Exercise and Game-Inspired Balance Training Program on Balance, Mobility, and Fall-Related Outcomes in Individuals With Multiple Sclerosis: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 28 May 2026
Brief summary (registry, in English)
Falls and balance impairments are common in individuals with multiple sclerosis (MS) and may negatively affect mobility, independence, confidence in daily activities, and quality of life, while increasing the risk of injury. This randomized controlled trial investigated the effects of a 6-week combined Otago-based and game-inspired balance-training program on static balance, functional mobility, fear of falling, and perceived walking ability in individuals with MS. Thirty participants with MS were randomly allocated to either an intervention group or an active control group. Both groups received fall-prevention counselling and performed home-based Otago-related exercises three times per week. The intervention group additionally received one supervised balance-training session per week using colored-circle and Twister-inspired task-oriented exercises. Outcomes were assessed at baseline and immediately after the intervention period using the FICSIT-4 for static balance, the Timed Up and Go test for functional mobility, the Falls Efficacy Scale-International (FES-I) for fear of falling, and the 12-item Multiple Sclerosis Walking Scale (MSWS-12) for perceived walking limitations.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 30 (actual)
- First submitted
- 28 Dec 2025
- Start date
- 1 Feb 2026
- Primary completion date
- 10 May 2026
- Lead sponsor
- International Hellenic University
- Diseases
- Multiple sclerosis
- NCT number
- NCT07331350
What you commit to
- Study type: Interventional
- Participants enrolled: 30
- From 1 Feb 2026 to the primary completion date, 10 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of other neurological, musculoskeletal, or medical conditions that could significantly affect balance or mobility.
Other
- Acute relapse of multiple sclerosis at the time of enrollment.
- Participation in another structured balance or fall-prevention program during the study period.
Who the study is looking for
- Confirmed diagnosis of multiple sclerosis according to the 2010 McDonald criteria.
- Age between 18 and 65 years.
- Ability to ambulate independently with or without an assistive device.
- Ability to understand and follow exercise instructions.
- Written informed consent prior to participation.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| International Hellenic University Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.