NCT07335315Recruiting
Evaluation of Intraoperative Contrast Enhanced Ultrasound for the Identification of Pituitary Adenoma in Cushing's Disease Compared to Other Pituitary Tumors
Source: ClinicalTrials.gov · Last updated 13 Jan 2026
Brief summary (registry, in English)
This pilot and feasibility study aims to combine recent advances in ultrasound imaging, specifically an endonasal transducer array and contrast enhanced ultrasound, to offer an intraoperative image-guided solution for lesion-specific surgical resection to impact clinical outcome. Should this imaging approach help isolate specific lesions and prevent surgical resection of normal pituitary tissue in this first-in-humans study, then the results will provide clinical data for a much larger multi-center clinical trial.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 110 (estimated)
- First submitted
- 5 Jan 2026
- Start date
- 19 Jun 2024
- Primary completion date
- Jan 2027
- Lead sponsor
- Mayo Clinic
- Diseases
- Childhood cancers
- NCT number
- NCT07335315
What you commit to
- Study type: Observational
- Planned participants: 110
- From 19 Jun 2024 to the primary completion date, Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Women of child-bearing potential with a positive pregnancy test prior to procedure.
Other illness
- Patients who have known or suspected hypersensitivity to microbubble contrast agents or its components such as polyethylene glycol (PEG).
- Patients who have right to left, bi-directional, or transient right to left cardiac shunts.
- Patients who have hypersensitivity to perflutren.
- For Non-Contrast Based Protocol:
Other
- Patients who are unable to consent (or if their legal guardian/representative decline to consent)
- Patients who are unable to consent (or if their legal guardian/representative decline to consent)
Who the study is looking for
- Diagnosis of Cushing disease or required resection for non-corticotroph adenomas
- Agree to transsphenoidal resection.
- Patients undergoing any pituitary surgery with the study designated neurosurgeons.
- Patients whose procedures require the use of an intra-operative BK ultrasound without contrast.
Criteria the registry did not label
- For Contrast Based Protocol:
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.