A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs

Criteria the registry did not label

• Inclusion Criteria:
  • Participant must be ≥18 years or the legal age at the time of signing the informed consent form.
  • Histologically or cytologically confirmed diagnosis of adenocarcinoma of the prostate.
  • Documented metastatic disease.
  • Serum testosterone levels ≤ 50 ng/dL.
  • Evidence of disease progression with one of the following:
  • PSA progression defined by a minimum of 3 rising PSA levels with an interval of ≥ 1 week between each determination.
  • Radiographic progression of soft tissue disease by RECIST v1.1 with or without PSA progression.
  • Radiographic progression of bone metastasis with 2 or more documented new bone lesions on a bone scan with or without PSA progression.
  • ECOG performance status score of 0 or 1.
  • Adequate bone marrow and organ function.
  • Part A (Module 1)
  • (a) Part A1 dose escalation: at least 1 prior ARPI and, if applicable, at least 1 taxane-based chemotherapy (regardless of whether in HSPC or CRPC setting).
  • (b) Part A2 backfill: at least 1 but no more than 2 prior ARPIs and, if applicable, at least 1 but no more than 2 prior taxane-based chemotherapies (regardless of whether in HSPC or CRPC setting).
  • Part B (Module 1)
  • (a) B1/B2 dose optimization/expansion: at least 1 but no more than 2 prior ARPIs and, if applicable, at least 1 but no more than 2 prior taxane-based chemotherapies (regardless of whether in HSPC or CRPC setting).
  • (b) B3 dose expansion (no taxane cohort): at least 1 but no more than 2 prior ARPIs for metastatic prostate cancer (regardless of whether in HSPC or CRPC setting). No prior taxane is allowed for inclusion in this cohort.
• Exclusion Criteria:
  • Participants with pathological finding consistent with any presence of small cell carcinoma, predominant neuroendocrine carcinoma, or any predominant histology other than prostate adenocarcinoma.
  • Brain metastases, or spinal cord compression.
  • Any clinically significant cardiac disorders including QT prolongation, abnormal electrocardiogram (ECG).
  • Any clinically significant cardiovascular diseases including symptomatic heart failure, uncontrolled hypertension, acute coronary syndrome, cardiomyopathy, valvular heart disease, atrial fibrillation, stroke.
  • Active gastrointestinal disease or other condition that will interfere significantly with the absorption, distribution, metabolism of AZD9750 and relevant combination IMPs.
  • Participants with any known predisposition to bleeding (eg, active peptic ulceration, recent \[within 6 months\] hemorrhagic stroke, proliferative diabetic retinopathy).
  • Prior treatment with an AR-PROTAC.
  • Other protocol-defined inclusion/exclusion criteria apply.