IAT-MeVO Trial Domain Within the ACT-GLOBAL Adaptive Platform Trial

Prior treatment

• Concurrent multiple (≥2) intracranial arterial occlusions;
• Concurrent participation in another investigational drug or device study that could interfere with the present trial;

Other illness

• Any evidence of intracranial hemorrhage on qualifying imaging;
• Any terminal disease with life expectancy \<1 year;

Lab values

• Clinical assessment of conditions unsuitable for interventional therapy (e.g., severe contrast agent allergy or absolute contraindications to iodine contrast agent; severe renal insufficiency, glomerular filtration rate \< 30ml/min or serum creatinine \> 220μmol/L (2.5 mg/dl));
• Unsuitable for arterial thrombolytic therapy (e.g., known history of hereditary or acquired hemorrhagic disease and/or platelet count \<50×109/L; abnormal coagulation function (INR\>1.7); oral anticoagulants were taken within 24 - 48 hours before onset within APTT \> 3 times normal; recent medical history or clinical manifestations of brain tumors other than meningiomas);

Other

• Suspected cerebral vasculitis, septic embolism, or infective endocarditis as the cause of vessel occlusion;
• Suspected arterial dissection;
• Pregnancy or lactation;
• Other circumstances that participation is not deemed appropriate.

• Age ≥ 18 y;
• Diagnosed as acute ischemic stroke;
• Isolated medium distal vessel occlusion (i.e. an occlusion of the M2, the M3/M4 segment of the MCA, the A1/ A2/A3 segment of the ACA or the P1/P2/P3 segment of the PCA) confirmed by CT or MR Angiography;
• Time from onset (or last-seen-well) to randomization \< 24h;
• Has not received intravenous thrombolysis and is considered unsuitable for it based on the treating clinician's assessment.
• NIHSS ≥ 5, or NIHSS ≤ 4 with disabling deficit (e.g. severe aphasia, hemianopia, hemiplegia/loss of function in one side) or fluctuating symptoms at the time of randomization;
• For patients within 6 h of onset: No visually apparent hypodensity is observed on non-contrast CT compared with the contralateral white matter, or no hyperintensity is seen on fluid-attenuated inversion recovery (FLAIR) imaging; For patients presenting 6-24 h after onset: A perfusion imaging-based ischemic core mismatch ratio \>1.2 and an infarct core volume \<50 mL are required;
• Pre-stroke mRS ≤ 1；
• Patient/Legally Authorized Representative has signed the Informed Consent form.