NCT07337135Completed
Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery
Opioid-free Anesthesia vs Opioid-based Anesthesia / A Heavyweight Showdown - Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 25 Feb 2026
Brief summary (registry, in English)
This prospective randomized controlled trial aims to compare the clinical effectiveness and safety of opioid-free anesthesia (OFA) versus traditional opioid-based anesthesia (OBA) in adult patients undergoing laparoscopic bariatric surgery. The study evaluates postoperative pain, need for rescue analgesia, incidence of postoperative nausea and vomiting (PONV), intraoperative nociception monitoring (NOL index), and patient satisfaction. A total of 60 patients were randomized into two parallel groups receiving either OFA or OBA according to standardized anesthetic protocols.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 10 Dec 2025
- Start date
- 2 Oct 2023
- Primary completion date
- 19 Apr 2024
- Lead sponsor
- Hospital dos Lusíadas
- Diseases
- Obesity
- NCT number
- NCT07337135
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 2 Oct 2023 to the primary completion date, 19 Apr 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindications to any of the drugs used in either anesthetic protocol (dexmedetomidine, ketamine, lidocaine, remifentanil, etc.);
Other illness
- History of substance abuse;
- Severe psychiatric disease;
Other
- Pregnancy;
- Inability to comply with study procedures;
- Refusal or inability to provide informed consent.
Who the study is looking for
- Age ≥ 18 years;
- Body mass index (BMI ≥ 35 kg/m² with associated comorbidities) or BMI ≥ 40 kg/m²;
- Scheduled for elective laparoscopic bariatric surgery;
- Ability to provide informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Lusíadas Amadora - Lusíadas Saúde, S.A. Coordinator of this site? Confirm its status | Amadora | Portugal | Unknown status |
Related publications
- Opioid-free versus opioid-based anesthesia in laparoscopic bariatric surgery: an exploratory randomized pilot trial.BMC Anesthesiol · 2026 · PMID 42185786
This page is information, not medical advice. Discuss any trial with your doctor.