NCT07339280Enrolling by invitation
Probiotics in COPD: Effects on Symptoms, Lung Function, and Inflammation
"The Effect of Probiotics on the Degree of Dyspnea, Lung Function, and Inflammatory Mediators in Patients With Chronic Obstructive Pulmonary Disease (COPD)."
Source: ClinicalTrials.gov · Last updated 21 Apr 2026
Brief summary (registry, in English)
The goal of this randomized, placebo controlled, double-blind clinical trial is to find out whether a probiotic supplement can help adults with chronic obstructive pulmonary disease (COPD) breathe better and better control their symptoms. The study will try to answer does taking a probiotic supplement, compare with a placebo, reduce shortness of breath, does it improve daily COPD symptoms or change stool patterns by using validated questionnaires; does it affect lung function or inflammation. The results of this study may contribute to a better understanding of the disease, the application of new therapeutic options, and provide a foundation for future research.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 2 Jan 2026
- Start date
- Mar 2026
- Primary completion date
- Sept 2027
- Lead sponsor
- University Hospital of Split
- Diseases
- COPD
- NCT number
- NCT07339280
What you commit to
- Study type: Interventional
- Planned participants: 60
- From Mar 2026 to the primary completion date, Sept 2027
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- patients on long-term systemic corticosteroid and immunosuppressive therapy (oral or intravenous form) as well as antifungal therapy,
- patients who have recently participated in other clinical trials or have received experimental therapy,
- patients with active alcoholism or drug addiction,
- patients who have recently undergone surgery,
- patients who have taken any probiotic preparations within one month before the start of the study,
Other illness
- patients diagnosed with serious comorbidities such as severe cardiovascular diseases (severe heart failure, acute coronary syndrome, or percutaneous coronary intervention within 6 months, uncontrolled tachy/bradyarrhythmias), patients with severe renal failure and a placed central venous catheter, patients with severe liver damage (Child-Pugh class C), patients with infectious hepatitis or HIV, active bloody diarrhea;
- patients who have had a stroke within the past 3 months;
- patients who have had a COPD exacerbation within the past two months and are not in a stable condition,
- patients with a history of lung surgery or serious respiratory diseases other than COPD (active tuberculosis, sarcoidosis, pulmonary fibrosis, severe bronchiectasis, pulmonary aspergillosis, etc.),
- patients with a history of severe allergic reactions or hypersensitivity to the components of the probiotic preparation,
- patients with severe psychiatric diagnoses or those with significant physical or cognitive limitations that would interfere with following the study protocol,
Other
- patients undergoing active oncological and hematological treatment;
- transplanted patients, including allograft recipients;
- patients diagnosed with asthma,
- pregnant or breastfeeding women,
- patients whose COPD treatment is changed during the course of the study.
Who the study is looking for
- Patients with a previously established diagnosis of COPD, regardless of the degree of airflow obstruction on pulmonary function testing.
- Age over 18 years, regardless of sex.
- Stable disease without exacerbations during the past two months (8 weeks).
- Stable disease without changes to maintenance therapy during the past two months (8 weeks).
- Patients with an mMRC score of 1 or higher.
- Signed informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| General Hospital Karlovac Coordinator of this site? Confirm its status | Karlovac | Croatia | Unknown status |
| General Hospital Sibenik Coordinator of this site? Confirm its status | Šibenik | Croatia | Unknown status |
| University Hospital Split Coordinator of this site? Confirm its status | Split | Croatia | Unknown status |
| General Hospital Vinkovci Coordinator of this site? Confirm its status | Vinkovci | Croatia | Unknown status |
| University Hospital Centre "Sestre Milosrdnice" Coordinator of this site? Confirm its status | Zagreb | Croatia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.