NCT07340125Recruiting
Pistachio Snacking and Metabolic Flexibility
Effects of Pistachio Snacking on Metabolic Flexibility in Healthy Overweight and Obese Adults
Source: ClinicalTrials.gov · Last updated 14 Jan 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 17 Dec 2025
- Start date
- 1 Sept 2025
- Primary completion date
- 1 Aug 2026
- Lead sponsor
- University of South Carolina
- Diseases
- Obesity
- NCT number
- NCT07340125
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 1 Sept 2025 to the primary completion date, 1 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Allergies to nuts, especially tree nuts
- Self-repoted health or disease state that may influence study outcomes, including known metabolic or endocrine disorder (e.g. prediabetes, type 1 or type 2 diabetes, or polycystic ovary syndrome), cardiovascular diseases, neuromuscular disorders, musculoskeletal disorders; current or recent history of cancer/cancer treatment (within the past year)
- History of gastrointestinal surgery, hysterectomy
Other
- Has a pacemaker
- Following a diet that is restrictive or eliminates certain food group/types
- For women: pregnant or thinking of becoming pregnant during the time of participation, pregnant within the last year, currently breastfeeding, or known to be perimenopausal
Who the study is looking for
- Males and Females
- Age: 25-45 years
- Overweight or obese (BMI=25.0-34.9 kg/m²)
- Poor sleep quality (Pittsburgh Sleep Quality Index ≥ 5)
- Healthy (no diagnosed metabolic, cardiovascular, sleep, or other health condition that may significantly alter metabolism, sleep, or ability to participate in the exercise test)
- Not meeting weekly physical activity recommendations (\<150 min moderate-intensity exercise, \<75 minutes of vigorous-intensity exercise, and \<2 days of strength training)
- Not following a diet that is restrictive or eliminates certain food group/types
Age in the registry: 25 years to 45 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Public Health Research Center: Clinical Exercise Research Center Coordinator of this site? Confirm its status | Columbia | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.