NCT07341217Recruiting
Chemo Brain Prehab Project
Chemo Brain Prehab Project: Improving Brain Health After Chemotherapy Through Prehabilitation
Source: ClinicalTrials.gov · Last updated 9 Sept 2026
Brief summary (registry, in English)
Colorectal cancer is 37% higher in the North West than the national average and is treated by chemotherapy, including fluorouracil, capecitabine, and oxaliplatin. A side effect of these drugs is loss of memory, forgetfulness, and general brain fog, which can persist for months after the end of treatment. These symptoms are collectively known as 'chemo-brain'. An existing prehabilitation intervention that has been previously developed will be used, which increases fitness and reduces hospital length of stay in colorectal cancer surgery patients, to try to improve the symptoms of chemo-brain in those undergoing chemotherapy and improve quality of life.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 86 (estimated)
- First submitted
- 18 Dec 2025
- Start date
- 7 Jul 2026
- Primary completion date
- 16 Sept 2027
- Lead sponsor
- Dr. Chris Gaffney
- Diseases
- Colorectal cancer
- NCT number
- NCT07341217
What you commit to
- Study type: Interventional
- Planned participants: 86
- From 7 Jul 2026 to the primary completion date, 16 Sept 2027
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving palliative care.
Other illness
- Presence of comorbidities that may significantly alter the metabolic response to exercise (e.g., diabetes mellitus).
- Any contraindication to the multivitamin supplementation (Forceval), including known hypercalcaemia, haemochromatosis, peanut or soya allergy, current use of phenytoin or tetracycline antibiotics, and clinically significant impaired renal or hepatic function.
- Evidence of pre-existing cognitive impairment, including diagnosis of dementia, other neurodegenerative disorders (e.g., Alzheimer's disease), or clinically indicated mild cognitive impairment.
- Diagnosis of atrial fibrillation and haematological malignancy.
- Presence of synchronous cancer.
- Structured exercise refers to planned and organised physical activity, such as gym workouts, exercise classes or a team sport, which are designed to improve or maintain physical fitness, often with instruction, rules, and goals.
Other
- Participants without home internet access will be excluded due to the online delivery of the exercise programme.
- Diagnosis of profound hearing loss.
Who the study is looking for
- Individuals with stage II or III colorectal cancer undergoing chemotherapy with fluorouracil, capecitabine, or oxaliplatin.
- Aged 60-85 years old.
- Fluent in English
- Male and female participants
- Not engaged in structured exercise training\* within the six months before providing consent.
Age in the registry: 60 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| East Lancashire Teaching Hospitals NHS Trust Coordinator of this site? Confirm its status | Blackburn | United Kingdom | Recruiting |
| University Hospitals Morecambe Bay Trust, Royal Lancaster Infirmary Coordinator of this site? Confirm its status | Lancaster | United Kingdom | Not yet recruiting |
| The Clatterbridge Cancer Centre NHS Foundation Trust Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Recruiting |
| Lancashire Teaching Hospitals NHS Trust Coordinator of this site? Confirm its status | Preston | United Kingdom | Not yet recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.