NCT07343427Active, not recruiting
Impact of GON PRF on Central Sensitization in Migraine Patients
Central Sensitization and Migraine Disability Following Greater Occipital Nerve Pulsed Radiofrequency: A Prospective Observational Study
Source: ClinicalTrials.gov · Last updated 12 May 2026
Brief summary (registry, in English)
Background: Central sensitization and cutaneous allodynia are key mechanisms implicated in migraine chronification and disability. Pulsed radiofrequency (PRF) of the greater occipital nerve (GON) has emerged as a neuromodulatory intervention for refractory headache disorders; however, its effects on central sensitization remain insufficiently characterized. Objective: To prospectively evaluate changes in central sensitization, allodynia, and migraine-related disability following GON pulsed radiofrequency in patients with migraine. Methods: In this prospective observational study, adult patients with episodic or chronic migraine undergoing ultrasound-guided GON pulsed radiofrequency were evaluated at baseline and at 1 and 3 months post-procedure. Central sensitization was assessed using the Central Sensitization Inventory (CSI), cutaneous allodynia using the Allodynia Symptom Checklist (ASC-12), and migraine-related disability using the Migraine Disability Assessment Scale (MIDAS). Monthly headache days and acute medication use were also recorded. Results: Changes in CSI, ASC-12, MIDAS scores, headache frequency, and acute medication use over follow-up were analyzed using repeated-measures statistical methods. Conclusions: This study provides prospective data on sensory and clinical outcomes following GON pulsed radiofrequency, contributing to the understanding of its potential role in modulating central sensitization in migraine.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 7 Jan 2026
- Start date
- 1 Feb 2026
- Primary completion date
- 1 Jun 2026
- Lead sponsor
- Ankara City Hospital Bilkent
- Diseases
- Migraine
- NCT number
- NCT07343427
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 1 Feb 2026 to the primary completion date, 1 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of other primary headache disorders (e.g., cluster headache, tension-type headache as the primary diagnosis)
- Secondary headache disorders, including headache attributed to structural, infectious, inflammatory, or vascular causes
- Prior greater occipital nerve pulsed radiofrequency treatment within the past 12 months
- History of cervical spine surgery, significant cervical trauma, or structural pathology that may interfere with the procedure
- Known coagulopathy or current use of anticoagulant therapy that cannot be safely interrupted
- Local infection at or near the planned injection site
- Severe uncontrolled psychiatric or neurological disorders that may impair study participation or questionnaire reliability
- Pregnancy or breastfeeding
- Inability to comply with follow-up visits or study procedures
Who the study is looking for
- Adults aged 18 years or older
- Diagnosis of episodic or chronic migraine according to the International Classification of Headache Disorders, 3rd edition (ICHD-3)
- Planned to undergo ultrasound-guided greater occipital nerve pulsed radiofrequency as part of routine clinical care
- Ability to complete self-reported questionnaires (CSI, ASC-12, MIDAS)
- Willingness and ability to provide written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ankara Bilkent City Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.