Personalisation of Mean Arterial Pressure in Adult Patients With Cardiogenic Shock

Prior treatment

• Chronic dialysis or presence of renal replacement therapy criteria at inclusion ;
• Recovered cardiopulmonary arrest within 7 days prior to inclusion;

Lab values

• Chronic kidney disease stage G4 (defined by an eGFR between 15-29 ml/min/1.73 m²) or G5 (defined by an eGFR less than 15 ml/min/1.73 m²) according to the KDIGO CKD classification at inclusion;
• Hypersensitivity to norepinephrine tartrate or to any of the following excipients: sodium chloride, hydrochloric acid or sodium hydroxide water for injectable preparations;

Other

• Catecholamine infusion for more than 24 consecutive hours;
• CVP \< 5 mm Hg at inclusion;
• MAP \> 70 mmHg at inclusion;
• Patient already on mechanical circulatory support at inclusion before enrollment (patients who receive support after inclusion will not be excluded);
• Primary diagnosis of tamponade, pulmonary embolism, or septic shock;
• Absence of central venous access;
• Known pregnancy or current breastfeeding;
• Under legal guardianship, curatorship, or judicial protection.

• Aged ≥18 years
• Cardiogenic shock state, according to the consensus definition,
• SCAI (Society for Cardiovascular Angiography and Interventions) classification ≥ C
• Consent from the patient or close relative / trusted person or emergency inclusion procedure
• Benefiting fromciary of a social security scheme