NCT07347665Recruiting
Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke With Occlusion of the M2 Segment of Middle Cerebral Artery
Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke With Occlusion of the M2 Segment of Middle Cerebral Artery (the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism-M2 Occlusion Trial: RESCUE-M2O Trial)
Source: ClinicalTrials.gov · Last updated 17 Jul 2026
Brief summary (registry, in English)
RESCUE-M2O trial is a prospective, open label, blinded endpoint (PROBE), two-arm, randomized, controlled, post-market study to assess the efficacy and safety of endovascular therapy for acute ischemic stroke with occlusion of the M2 segment of the middle cerebral artery.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 9 Jan 2026
- Start date
- 1 Dec 2025
- Primary completion date
- 31 Mar 2028
- Lead sponsor
- Hyogo Medical University
- Diseases
- Stroke
- NCT number
- NCT07347665
What you commit to
- Study type: Interventional
- Planned participants: 200
- From 1 Dec 2025 to the primary completion date, 31 Mar 2028
- 3 sites in 3 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Known allergy (more severe than skin rash) to contrast agents
- Evidence of acute intracranial hemorrhage on CT (or MRI)
Lab values
- High risk of hemorrhage (platelet \< 40,000/ul, APTT \> 50 sec or PT-INR \> 3.0)
Other
- Occlusion of the anterior temporal artery, duplicate M1, or accessory M1
- Occlusion of multiple major intracranial arteries
- Difficulty in endovascular access due to tortuous vascular anatomy
- Significant mass effect with midline shift on CT (or MRI)
- Pregnant or potentially pregnant
- Clinical evidence of chronic occlusion
- Participating in any other therapeutic investigational trial
- Judgment of the investigator to be non-compliant or uncooperative during the study
Who the study is looking for
- Acute cerebral infarction
- Aged 18-84 years
- NIHSS score at admission ≥ 8
- Prestroke mRS scores of 0-1 (able to carry out all usual activities)
- Occlusion of the M2 segment of MCA on digital subtraction angiography
- ASPECTS ≥ 8 or DWI-ASPECTS ≥ 8
- Ineligible or failed intravenous tPA (no recanalization within 30 min after injection)
- Randomization can be completed within 24 h from the last known well time
- EVT can be initiated within 30 min from randomization.
- The patient or their legally authorized representative has signed the informed consent form.
Age in the registry: 18 years to 84 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hyogo Medical University Coordinator of this site? Confirm its status | Nishinomiya | Japan | Recruiting |
| Thammasat University Hospital Coordinator of this site? Confirm its status | Khlong Luang | Thailand | Recruiting |
| S.I.S Can Tho International General Hospital Coordinator of this site? Confirm its status | Can Tho | Vietnam | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.