NCT07348887Recruiting
Phase II Study of Daily Adaptive Radiotherapy for Submandibular Gland-sparing in Head and Neck Cancer
Phase II Randomized Trial of RT-Led Daily Adaptive Radiotherapy for Submandibular Gland-Sparing in Head and Neck Cancer (RTL-DART)
Source: ClinicalTrials.gov · Last updated 4 Mar 2026
Brief summary (registry, in English)
This is a randomized, single centre, single blinded prospective study comparing the standard of care imaging guided radiation therapy and daily adaptive radiotherapy (ART) for submandibular gland-sparing in head and neck cancer
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 25 Nov 2025
- Start date
- 15 Oct 2025
- Primary completion date
- 1 Oct 2029
- Lead sponsor
- University Health Network, Toronto
- Diseases
- Head and neck cancer
- NCT number
- NCT07348887
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 15 Oct 2025 to the primary completion date, 1 Oct 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Underlying salivary dysfunction prior to treatment judged by investigator to affect likelihood of benefit from ART
Other illness
- As judged by investigator evidence of systemic disease that makes unsuitable for study
Other
- Pregnancy
Who the study is looking for
- Age ≥ 18 years
- Histologically proven Squamous Cell carcinoma of head and neck
- Bilateral neck being treated
- At least one level 1b not being treated electively and with no target structure, other than elective level II/III, \<1cm to spared SMG
- ECOG PS 0-2
- Planned for curative (chemo)radiotherapy
- Able to receive and understand verbal and written information regarding study and able to give written informed consent
- Be able to lie comfortably on back and to wear immobilization for up to 1 hour
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Princess Margaret Cancer Centre Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.