NCT07350772Not yet recruiting
It is an Observational Study That Compare Prognosis of Typical and Atypical Systemic Lupus Erythematosus Presentation
Atypical Lupus Presentations and Their Prognostic Implications
Source: ClinicalTrials.gov · Last updated 20 Jan 2026
Brief summary (registry, in English)
Atypical presentations of SLE including unusual initial symptoms, predominant organ involvement, late-onset disease and ANA-negative remain poorly characterized. These forms are often associated with delayed diagnosis and potentially worse clinical outcomes. Most existing studies focus on isolated rare manifestations rather than analyzing atypical SLE as a cohesive category. Understanding these differences is crucial and this study aims to compare atypical and typical SLE presentations to clarify variations in prognosis, treatment requirements and subsequent organ involvement.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 27 Dec 2025
- Start date
- Feb 2026
- Primary completion date
- Feb 2027
- Lead sponsor
- Sohag University
- Diseases
- Lupus (SLE)
- NCT number
- NCT07350772
What you commit to
- Study type: Observational
- Planned participants: 400
- From Feb 2026 to the primary completion date, Feb 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients whose initial symptoms are clearly attributable to infection, sepsis or another non-SLE condition.
- Patients with chronic pre-existing diseases that may mimic or obscure the initial SLE presentation (e.g. primary epilepsy, primary pulmonary hypertension, chronic liver or GI disease).
Other
- Patients in whom onset features cannot be reliably classified as typical or atypical due to mixed or unclear presentation.
- \-
Who the study is looking for
- Patients diagnosed as SLE according toSLICC 2012Classification Criteria\[13\] :
- Patients presented with typical lupus presentation:
- age of onset (20-50)
- common initial manifestations as constitutional manifestations,arthritis, mucocutaneousmanifestationslike malar rash, photosensitivity and hair falling.
- patients with ANA positive.
- Patients presented with atypical lupus presentation:
- any clinical presentation not belonging to classic common SLE onset features, including but not limited to:
- Neuropsychiatric onset: seizure, psychosis, aseptic meningitis, transverse myelitis
- Cardiopulmonary onset: pulmonary hypertension, acute pneumonitis, myocarditis, pulmonary hemorrhage
- Gastrointestinal onset: mesenteric vasculitis, intestinal pseudo obstruction, pancreatitis
- Hematologic severe onset: isolated severe thrombocytopenia, autoimmune hemolytic anemia, thrombotic microangiopathy
- Dermatologic atypical onset: bullous lupus, panniculitis, vasculitic ulcers
- Myositis
- Fever of unknown origin (FUO) as sole initial presentation
- Thrombotic events
- Generalized lymphadenopathy.
- Patients with dominant organ affection.
- patients with late onset SLE.
- patients with ANA negative SLE. C.Patients who can provide informed consent.
Age in the registry: 19 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sohag university hospitals,sohag ,sohag Coordinator of this site? Confirm its status | Sohag | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.