NCT07352176Not yet recruiting
Study on the Effectiveness and Safety of CLE Combined With Cryobiopsy for Diagnosis of Pulmonary Lesions
Study on the Effectiveness and Safety of Confocal Laser Endomicroscopy Combined With Ultrafine Cryoprobe for Biopsy Diagnosis of Pulmonary Lesions
Source: ClinicalTrials.gov · Last updated 20 Jan 2026
Brief summary (registry, in English)
Forty subjects meeting the inclusion and exclusion criteria were recruited at a single center and signed informed consent forms. Among them, 20 patients in the diffuse group and 20 patients in the localized group were randomly assigned to the conventional radial endobronchial ultrasound combined with cryobiopsy group (conventional group) and the confocal laser endomicroscopy combined with cryobiopsy group (combined group). During the operation, the operator manipulated the bronchoscope to reach the lesion. After confirming the arrival at the lesion using radial endobronchial ultrasound/confocal laser endomicroscopy, cryobiopsy was performed, and the size of the sample was recorded. CBCT scanning was conducted after cryobiopsy. If there was no hole-in-lesion image, cryobiopsy was performed again under CBCT guidance. CBCT scanning was performed after biopsy to determine whether there were any adverse events.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 11 Jan 2026
- Start date
- 1 Feb 2026
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Guangzhou Medical University
- Diseases
- Lung cancer
- NCT number
- NCT07352176
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 1 Feb 2026 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who cannot discontinue therapeutic anticoagulants within an appropriate time interval before surgery;
Other illness
- Patients with uncorrectable coagulation disorders;
- Patients with severe liver or kidney dysfunction, mental illness, etc.;
Other
- Patients with contraindications to anesthesia or bronchoscopy;
- Pregnant or lactating patients;
- Patients without a clear histological or clinical diagnosis;
- Subjects deemed unsuitable for participation in this study by the investigator.
Who the study is looking for
- Patients over 18 years old with lung lesions indicated by chest CT;
- Preoperative CT indicates that the lung lesion to be biopsied has a bronchus leading to it;
- Able to understand and voluntarily sign the written informed consent form. -
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510163 Coordinator of this site? Confirm its status | Guangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.