NCT07353658Not yet recruiting

Effect of Intermittent Enteral Feeding in Severe Stroke

The Effect of Intermittent Versus Continuous Enteral Feeding on Outcomes in Severe Stroke: An Exploratory Study

Source: ClinicalTrials.gov · Last updated 20 Jan 2026

Brief summary (registry, in English)

This is a single-center, randomized, exploratory clinical trial investigating whether intermittent enteral feeding improves outcomes compared to continuous feeding in patients with severe stroke. The study will enroll 60 patients to evaluate the impact on 90-day all-cause mortality, neurological function, nutritional status, and safety. It will also explore underlying mechanisms through analysis of metabolic profiles, circadian gene expression, and gut microbiota.

Status (registry): Not yet recruiting
Study type: Interventional
Enrollment: 60 (estimated)
First submitted: 25 Dec 2025
Start date: 5 Jan 2026
Primary completion date: 31 Dec 2026
Lead sponsor: Xijing Hospital
Diseases: Stroke
NCT number: NCT07353658

What you commit to

Study type: Interventional
Planned participants: 60
From 5 Jan 2026 to the primary completion date, 31 Dec 2026
No sites listed in no country
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

Before joining the group, he had received total parenteral nutrition treatment.
There are concomitant diseases that will interfere with outcome evaluation and/or follow-up.

Other illness

Dementia or severe disability before onset (mRS≥3)

Other

There are contraindications to enteral nutrition.
Unstable vital signs
Participating in other interventional clinical trials.
Other circumstances in which the study cannot be completed.

Who the study is looking for

Age ≥18 years old
It was definitely diagnosed as acute stroke by clinical imaging.
Enteral nutrition program can be started within 72 hours of onset.
Baseline GCS≤12 or NIHSS≥11
There is nutritional risk (NRS 2002≥3), Wadian drinking water test≥ 3 or there is consciousnessdisorder,it is estimated that you need to receive nutritional support treatment for ≥7 days
Obtain informed consent

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

This page is information, not medical advice. Discuss any trial with your doctor.