Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

Prior treatment

• Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening)
• Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
• Have had within 90 days prior to screening:
  • heart attack
  • stroke
  • coronary artery revascularization
  • unstable angina, or
  • hospitalization due to congestive heart failure
• Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Other illness

• Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
• Have an active knee infection
• Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure

• Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening
• Have a stable body weight (less than 5% body weight change) for 90 days prior to screening
• Have tried at least once to lose weight through diet but were unsuccessful
• Have osteoarthritis of the knee and at least one of the following conditions:
  • Be over 50 years old
  • Have morning knee stiffness that lasts about 30 minutes
  • Have a crackling or grinding sound or feeling in the knee