NCT07355231Not yet recruitingPhase 1/2
Lung Functional Avoidance Radiotherapy Using Hyperpolarized Xenon MRI
Source: ClinicalTrials.gov · Last updated 1 Sept 2026
Brief summary (registry, in English)
Cancer radiation treatment plans that employ lung functional avoidance methods require 3D maps that differentiate regions of healthy lung function from regions of functional compromised tissue to deliver sufficient dose to the tumor while preserving as much functioning lung as possible. Hyperpolarized xenon-129 MRI can provide maps of ventilatory function and gas exchange to the bloodstream. Improving treatment plans based on this novel imaging modality could reduce risk or severity of radiation pneumonitis and improve post-treatment quality of life.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 19 Jan 2026
- Start date
- 1 Mar 2027
- Primary completion date
- 29 Feb 2028
- Lead sponsor
- Xemed LLC
- Diseases
- Lung cancer
- NCT number
- NCT07355231
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 10
- From 1 Mar 2027 to the primary completion date, 29 Feb 2028
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Active drug or alcohol dependence
Other illness
- A language, communication, cognitive or behavioral impairment that might interfere with fully informed participation in the study.
- History of uncompensated organ failure (i.e. organ failure that is not stabilized through medical intervention), which will be assessed by the PI.
Age
- Patients less than 18 years old
Other
- Patients known to be pregnant - a positive pregnancy test will be used to respectively exclude pregnant patients,
- Any known contraindication to MRI examination
- Anyone with an implanted metal device
- Inability to provide informed consent
- Homelessness or other unstable living situation
- Claustrophobia
- Subjects weighting more than 300 pounds.
- Subjects with chest size larger than the bore of MRI machine can accommodate
Who the study is looking for
- Patients over 18 years with a diagnosis of non-small lung cancer and planned for a definitive course of radiation therapy.
- Preferred patients will have had successful radiation therapy for a prior lung cancer and developed a secondary lung cancer for which are to be treated.
- Other de-nuovo lung cancer patients planned for radiation therapy with lung heterogeneity from natural co-morbidities (e.g., COPD stage 3+).
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.