NCT07355933Completed
Metabolic Flexibility and Metabolic Heath in Human Obesity
Metabolic Flexibility, Eating Behavior and Adipose Tissue Expandability: Role of This Triad in the Propensity to Human Obesity
Source: ClinicalTrials.gov · Last updated 27 Feb 2026
Brief summary (registry, in English)
This interventional study explores the relationship between improvements in metabolic health following weight loss and changes in whole-body fat mass and its distribution. The study focuses on adult men and women with excess body weight undergoing dietary energy restriction over 12 weeks. The primary research question is: Does a greater reduction in fat mass for a given weight loss correlate with more significant improvements in metabolic health?
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 74 (actual)
- First submitted
- 25 Jul 2025
- Start date
- 23 Sept 2022
- Primary completion date
- 6 Jan 2025
- Lead sponsor
- Jose Galgani
- Diseases
- Obesity
- NCT number
- NCT07355933
What you commit to
- Study type: Interventional
- Participants enrolled: 74
- From 23 Sept 2022 to the primary completion date, 6 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Individuals with physiological (pregnancy, lactation) or pathological (under drug therapy for and/or having cardiovascular, liver, kidney, thyroid diseases)
- conditions affecting energy metabolism or eating behavior
Other
- Subjects having low-fat (\<20% energy) or low-carbohydrate (\<45% energy) diets
- Smokers and alcohol abusers
Who the study is looking for
- males or females
- 30-55 y old
- physically inactive (\<600 MET´min/wk of self-reported moderate-vigorous physical activity
- stable body weight for at least the past 6 months (±2 kg)
- healthy according to medical history and routine hematology and biochemistry.
Age in the registry: 30 years to 55 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Avda. Libertador Bernardo O´Higgins 340. Santiago. Chile. Coordinator of this site? Confirm its status | Santiago | Chile | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.