NCT07356544Recruiting
Observational, Prospective, Multi-centric Study Exploring HER2 Mutations Incidence and Therapeutic Management in aNSCLC
HER2 in Advanced NSCLC: an Observational, Prospective, Multi-centric Study Exploring HER2 Mutations Incidence and Therapeutic Management in Italy. The HEROS Study - GOIRC-01-2022
Source: ClinicalTrials.gov · Last updated 5 Mar 2026
Brief summary (registry, in English)
The HEROS study is an Italian observational multicenter prospective study aimed to investigate the current diagnostic and therapeutical approach towards HER2 mutated NSCLC in clinical practice. The enrolment will start in September 2024 until September 2025. A 12-months follow-up window will be performed.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 14 Jan 2025
- Start date
- 12 Aug 2025
- Primary completion date
- 31 Jan 2027
- Lead sponsor
- Gruppo Oncologico Italiano di Ricerca Clinica
- Diseases
- Lung cancer
- NCT number
- NCT07356544
What you commit to
- Study type: Observational
- Planned participants: 50
- From 12 Aug 2025 to the primary completion date, 31 Jan 2027
- 22 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- \-
Who the study is looking for
- Cohort 1 (Prevalence study population)
- Male or female, aged at least 18 years.
- Pathologically confirmed diagnosis of NSCLC from September 2024 to September 2025.
- Locally advanced (IIIC), not amenable to multimodal approach (chemo-radiotherapy), or metastatic (IV) NSCLC according to TNM VIII edition.
- Enrolled in ATLAS project. Cohort 2 (HER2 mutations study population)
- Included in Cohort 1.
- Presence of HER2 mutation.
- Enrolled in ATLAS project. Cohort 3 (Prospective Biomarker Analysis population)
- Included in Cohort 2.
- Availability of tissue sample from the first 50 patients enrolled in cohort 2.
- Written informed consent (HEROS project) must be obtained before any study-related procedure.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (22)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centro di Riferimento Oncologico IRCCS di Aviano Coordinator of this site? Confirm its status | Aviano | Italy | Not yet recruiting |
| IRCCS "Giovanni Paolo II" Coordinator of this site? Confirm its status | Bari | Italy | Active, not recruiting |
| Arcispedale Sant'Anna Coordinator of this site? Confirm its status | Ferrara | Italy | Not yet recruiting |
| Ospedale Policlinico San Martino Coordinator of this site? Confirm its status | Genova | Italy | Not yet recruiting |
| Ospedale Versilia Coordinator of this site? Confirm its status | Lido di Camaiore | Italy | Active, not recruiting |
| Azienda Sanitaria Toscana Nord - Ovest Coordinator of this site? Confirm its status | Lucca | Italy | Active, not recruiting |
| Istituto Romagnolo per lo Studio dei Tumori IRST "Dino Amadori" Coordinator of this site? Confirm its status | Meldola | Italy | Not yet recruiting |
| ASST Grande Ospedale Metropolitano Niguarda Coordinator of this site? Confirm its status | Milan | Italy | Not yet recruiting |
| IRCCS Ospedale San Raffaele Coordinator of this site? Confirm its status | Milan | Italy | Not yet recruiting |
| Azienda Ospedaliero - Universitaria di Modena Coordinator of this site? Confirm its status | Modena | Italy | Active, not recruiting |
| IRCCS San Gerardo dei Tintori Coordinator of this site? Confirm its status | Monza | Italy | Not yet recruiting |
| AOU San Luigi Orbassano Coordinator of this site? Confirm its status | Orbassano | Italy | Not yet recruiting |
| Istituto Oncologico Veneto - IRCCS Coordinator of this site? Confirm its status | Padova | Italy | Recruiting |
| Azienda Ospedaliera - Universitaria di Parma Coordinator of this site? Confirm its status | Parma | Italy | Recruiting |
| Fondazione IRCCS Policlinico S. Matteo Coordinator of this site? Confirm its status | Pavia | Italy | Not yet recruiting |
| Azienda Ospedaliera di Perugia Coordinator of this site? Confirm its status | Perugia | Italy | Active, not recruiting |
| Azienda Ospedaliero - Universitaria di Reggio Emilia Coordinator of this site? Confirm its status | Reggio Emilia | Italy | Active, not recruiting |
| Azienda Ospedaliera San Camillo Forlanini Coordinator of this site? Confirm its status | Roma | Italy | Active, not recruiting |
| Istituto Nazionale dei Tumori Regina Elena IRCCS - IFO Coordinator of this site? Confirm its status | Roma | Italy | Not yet recruiting |
| Istituto Clinico Humanitas IRRCS Coordinator of this site? Confirm its status | Rozzano | Italy | Not yet recruiting |
| Azienda Sanitaria Universitaria Friuli Centrale (ASU FC) Coordinator of this site? Confirm its status | Udine | Italy | Not yet recruiting |
| Azienda Ospedaliera Universitaria Integrata Verona Coordinator of this site? Confirm its status | Verona | Italy | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.