NCT07357415Active, not recruitingPhase 3
A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight
A Phase 3b Study to Investigate the Efficacy and Safety of Different Retatrutide Dose Escalation Schemes in Participants Without Type 2 Diabetes Who Have Obesity or Overweight: A Randomized, Controlled, Double-Blind Trial
Source: ClinicalTrials.gov · Last updated 9 Jun 2026
Brief summary (registry, in English)
The purpose of this study is to investigate the efficacy and safety of different retatrutide dose escalation schemes in participants without type 2 diabetes who have obesity or overweight. Participation in the study will last about 113 weeks.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 600 (estimated)
- First submitted
- 16 Jan 2026
- Start date
- 24 Jan 2026
- Primary completion date
- Oct 2028
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT07357415
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 600
- From 24 Jan 2026 to the primary completion date, Oct 2028
- 35 sites in 3 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days before screening
- Have a prior or planned surgical treatment for obesity
- Have had within the past 90 days before screening:
- heart attack
- stroke
- hospitalization for unstable angina or heart failure
- Have taken weight loss drugs, including over-the counter medications within 90 days prior to screening
Other illness
- Have type 1 diabetes or type 2 diabetes
- Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
- Have New York Heart Association Functional Classification Class IV congestive heart failure
- Have a history of chronic or acute pancreatitis
Who the study is looking for
- Have a Body Mass Index (BMI) at screening
- ≥ 30 kilogram per square meter (kg/m2) OR
- ≥ 27 kg/m2 with presence of at least one of the following weight-related conditions at screening: high blood pressure, abnormal levels of lipid, obstructive sleep apnea, heart disease
- Have at least one unsuccessful attempt to lose weight by dieting
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (35)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cicemo Srl Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Stat Research S.A. Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Centro de Investigaciones Metabólicas (CINME) Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| CARDIAMET Investigaciones Médicas Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Centro Médico Viamonte Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Aggarwal and Associates Limited Coordinator of this site? Confirm its status | Brampton | Canada | Unknown status |
| Med Trust Research Coordinator of this site? Confirm its status | Courtice | Canada | Unknown status |
| Winterberry Research Inc. Coordinator of this site? Confirm its status | Hamilton | Canada | Unknown status |
| Diex Recherche Inc. Division Joliette Coordinator of this site? Confirm its status | Joliette | Canada | Unknown status |
| Milestone Research Inc. Coordinator of this site? Confirm its status | London | Canada | Unknown status |
| Diex Recherche Inc. Division Quebec Coordinator of this site? Confirm its status | Québec | Canada | Unknown status |
| Diex Recherche Inc. Division Sherbrooke Coordinator of this site? Confirm its status | Sherbrooke | Canada | Unknown status |
| Canadian Phase Onward Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Dr. Anil K. Gupta Medicine Professional Corporation Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| C.I.C. Mauricie inc. Coordinator of this site? Confirm its status | Trois-Rivières | Canada | Unknown status |
| Great Lakes Research Group, Inc. Coordinator of this site? Confirm its status | Bay City | United States | Unknown status |
| Brigham and Women's Hospital Diabetes Program Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| CAMC Institute for Academic Medicine Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
| Cedar Health Research Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Velocity Clinical Research, Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Cedar Health Research - Texas Native Health Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Cedar Health Research - Fort Worth Coordinator of this site? Confirm its status | Fort Worth | United States | Unknown status |
| Pacific Diabetes & Endocrine Center Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Care Access - Huntington Beach Coordinator of this site? Confirm its status | Huntington Beach | United States | Unknown status |
| New Phase Research And Development Coordinator of this site? Confirm its status | Knoxville | United States | Unknown status |
| NYC Research Inc. Coordinator of this site? Confirm its status | Long Island City | United States | Unknown status |
| Los Angeles Institute for Metabolic Research Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Monroe Biomedical Research - Louisville Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| New Horizon Research Center Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Weill Cornell Medical College Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Advanced Research Institute Coordinator of this site? Confirm its status | Ogden | United States | Unknown status |
| Arizona Research Center Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Care Access - Raleigh Coordinator of this site? Confirm its status | Raleigh | United States | Unknown status |
| Dominion Medical Associates, Inc. Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| Encore Medical Research - Weston Coordinator of this site? Confirm its status | Weston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.