NCT07358247Not yet recruiting
Postoperative Outcomes of Single-stapled Anastomosis Combined With Transanal Natural Orifice Specimen Extraction
Postoperative Outcomes of Transanal Transection and Single-stapled Technique Combined With Transanal Natural Orifice Specimen Extraction: a Single-center Retrospective Cohort Study
Source: ClinicalTrials.gov · Last updated 22 Jan 2026
Brief summary (registry, in English)
Natural Orifice Specimen Extraction (NOSE) eliminates the need for additional abdominal incisions in minimally invasive colorectal procedures, potentially reducing the risk of wound complications and postoperative pain. In the context of restorative Total Mesorectal Excision (TME), single-stapling (SS) techniques facilitate NOSE through transanal rectal transection, as opposed to the conventional double-stapling technique. This study aims to explore the potential advantages of NOSE combined with SS anastomosis compared to conventional abdominal extraction in minimally invasive restorative TME.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 190 (estimated)
- First submitted
- 13 Jan 2026
- Start date
- 31 Jan 2026
- Primary completion date
- 31 Mar 2026
- Lead sponsor
- Istituto Clinico Humanitas
- Diseases
- Colorectal cancer
- NCT number
- NCT07358247
What you commit to
- Study type: Observational
- Planned participants: 190
- From 31 Jan 2026 to the primary completion date, 31 Mar 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who underwent non-restorative procedures (including abdominoperineal resection or Hartmann's procedures).
- Patients who underwent open surgery.
- Patients with a concomitant diagnosis of Inflammatory Bowel Disease (IBD).
Other
- Patients who underwent immediate or delayed coloanal anastomosis.
- Patients who underwent unplanned conversion from minimally invasive to open approach.
Who the study is looking for
- Adult patients aged more than 18 years old at the time of surgery
- Patients with a histological diagnosis of rectal adenocarcinoma
- Patients who underwent surgery between January 2017 and January 2023
- Patients with a low rectal tumor meeting the Low Rectal Cancer Development Programme (LOREC) criteria
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IRCCS Humanitas Research Hospital Coordinator of this site? Confirm its status | Rozzano | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.