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NCT07358429Active, not recruiting

CPAP Therapy and Atrial Fibrillation Recurrence in OSA

Effects of CPAP Therapy on Atrial Fibrillation Recurrence in Patients With Obstructive Sleep Apnea: A Prospective Cohort Study

Source: ClinicalTrials.gov · Last updated 22 Jan 2026

Brief summary (registry, in English)

Obstructive sleep apnea (OSA) is a major modifiable risk factor for atrial fibrillation (AF). Continuous positive airway pressure (CPAP) therapy has been shown to improve cardiovascular outcomes; however, real-world data on its effect on AF recurrence remain limited. This prospective cohort study aims to evaluate the association between objective CPAP adherence and the risk of AF recurrence in patients with moderate-to-severe OSA and a history of paroxysmal AF. Patients will be followed for 12 months, with AF recurrence assessed using electrocardiography and Holter monitoring.

Status (registry)
Active, not recruiting
Study type
Observational
Enrollment
91 (actual)
First submitted
14 Jan 2026
Start date
1 Sept 2024
Primary completion date
30 Nov 2025
Lead sponsor
Medical University of Sofia
NCT number
NCT07358429

What you commit to

  • Study type: Observational
  • Participants enrolled: 91
  • From 1 Sept 2024 to the primary completion date, 30 Nov 2025
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Inability to obtain or tolerate CPAP therapy -

Other illness

  • End-stage chronic kidney disease

Lab values

  • Left ventricular ejection fraction \< 50%

Other

  • Permanent atrial fibrillation
  • Central sleep apnea

Who the study is looking for

  • Age ≥ 18 years
  • Diagnosed moderate-to-severe OSA
  • History of paroxysmal atrial fibrillation
  • Ability to initiate CPAP therapy
  • Written informed consent -

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
UMHAT "Tcaritca Joanna - ISUL"
Coordinator of this site? Confirm its status
SofiaBulgariaUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.