NCT07358663Recruiting
Treatment Outcomes for Portal Hypertension Esophageal and Gastric Varices
Assessment of Treatment Outcomes for Esophageal and Gastric Varices Secondary to Portal Hypertension
Source: ClinicalTrials.gov · Last updated 14 May 2026
Brief summary (registry, in English)
This study is a single-center, prospective cohort study based on real-world data. Patients with portal hypertension and esophagogastric varices were enrolled and divided into an endoscopic treatment group and a non-endoscopic treatment group (including patients receiving medical therapy, interventional procedures, or surgical treatment) according to whether they underwent endoscopic intervention. Baseline data, serum metabolites, CT imaging and endoscopic images, liver biopsy pathology, and other multi-omics data were integrated for both groups. Patients were followed up to compare adverse events after variceal treatment, including rebleeding and its causes, hepatic encephalopathy, ascites, subsequent treatments (such as regular endoscopic therapy, NSSB, and TIPS), and survival outcomes. Clinical characteristics of portal hypertension attributed to different etiologies, including hepatitis B, autoimmune liver disease, schistosomiasis, hematological disorders, and chemotherapy-induced liver injury, were compared. The efficacy and safety of endoscopic and interventional treatments for esophagogastric varices were evaluated. Factors influencing rebleeding rates among different treatment groups were analyzed, and reasons for inclusion in different groups were discussed.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1384 (estimated)
- First submitted
- 14 Jan 2026
- Start date
- 20 Jan 2026
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Shanghai Zhongshan Hospital
- Diseases
- High blood pressure
- NCT number
- NCT07358663
What you commit to
- Study type: Observational
- Planned participants: 1384
- From 20 Jan 2026 to the primary completion date, 31 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of peptic ulcer, gastric tumor, or other causes of gastrointestinal bleeding confirmed by imaging or gastroscopy.
Other
- CT images of inadequate quality or incomplete medical history data.
Who the study is looking for
- Clinical diagnosis of portal hypertension with esophagogastric varices.
- Underwent abdominal CT and gastroscopy examinations.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zhongshan Hospital,Fudan University Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.