NCT07359885Not yet recruiting
Prediction of Postoperative Pulmonary Complications in Thoracic Surgery
Prediction of Postoperative Pulmonary Complications in Thoracic Surgery: an Immuno-inflammatory Approach
Source: ClinicalTrials.gov · Last updated 22 Jan 2026
Brief summary (registry, in English)
Lung cancer is a common disease, and its treatment is lobectomy or pulmonary segmentectomy. In France, approximately 8,000 patients undergo this procedure each year, but it remains associated with significant Postoperative Pulmonary Complications (PPC). This surgical trauma triggers a multicellular and orchestrated immune response, necessary for defense against pathogens, as well as for inflammatory resolution and wound healing. Preoperative single-cell analysis of the patient's immune system is therefore a promising strategy for identifying biomarkers of postoperative pulmonary complications (PPC). Brice Gaudilliere's laboratory at Stanford University, in collaboration with the Paris-based startup Surge, has developed and patented a multivariate model integrating mass cytometry data, proteomic analyses, and clinical data collected before surgery to accurately predict surgical site complications after major abdominal surgery. However, no study has yet explored the identification of inflammatory biomarkers predictive of PPC after thoracic surgery.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 14 Jan 2026
- Start date
- 1 Jun 2026
- Primary completion date
- 1 Sept 2028
- Lead sponsor
- University Hospital, Rouen
- Diseases
- Lung cancer
- NCT number
- NCT07359885
What you commit to
- Study type: Observational
- Planned participants: 100
- From 1 Jun 2026 to the primary completion date, 1 Sept 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Surgery scheduled for a Friday
Other
- Minor patients
- Patients undergoing a pneumonectomy
- Pregnant or breastfeeding women
- Patients deprived of their liberty by an administrative or judicial decision, as well as those under legal protection, guardianship, or curatorship
Who the study is looking for
- Age ≥ 18 years
- ASA score ≤ 3
- Patients undergoing scheduled video-assisted or robot-assisted lobectomy, bilobectomy, or segmentectomy.
- Patients who have read and understood the information letter and do not object to the research.
- For women of childbearing age (non-sterile): effective contraception
- Menopausal (non-medically induced amenorrhea for at least 12 months)
- Patients covered by a social security scheme
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Service de Anesthésie-Réanimation Médecine périopératoire CHU de Rouen Coordinator of this site? Confirm its status | Rouen | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.