NCT07361653Not yet recruiting
The REVIVE Pivotal Study
A Prospective, Global, Multicenter, Randomized, Double Blind, Sham Controlled Study to EValuate the Safety and effectIVEness of the Ryme Medical Targeted Lung Denervation (TLD) Catheter in Patients With Moderate and Severe Symptomatic Chronic Obstructive Pulmonary Disease (COPD) - The REVIVE Pivotal Study
Source: ClinicalTrials.gov · Last updated 5 May 2026
Brief summary (registry, in English)
The goal of this study is to test whether a new treatment called the Ryme Medical Targeted Lung Denervation (TLD) Catheter is safe and effective for people with moderate to severe chronic obstructive pulmonary disease (COPD). The main questions it aims to answer are: 1. Does the TLD Catheter improve symptoms in people with COPD? 2. Is the TLD Catheter safe ? Researchers will compare the group receiving the TLD treatment to the group receiving a sham procedure to see if the treatment improves quality of life. Participants will: 1. Be randomly assigned to receive either the TLD treatment or a sham procedure. 2. Undergo the assigned procedure in a hospital setting. 3. Attend follow-up visits for health checks and breathing tests.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 300 (estimated)
- First submitted
- 21 Jan 2026
- Start date
- Jun 2026
- Primary completion date
- Dec 2028
- Lead sponsor
- Ryme Medical, Inc.
- Diseases
- COPD
- NCT number
- NCT07361653
What you commit to
- Study type: Interventional
- Planned participants: 300
- From Jun 2026 to the primary completion date, Dec 2028
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior lung intervention with device in place
Other illness
- Clinically significant serious or unstable medical conditions (e.g., heart disease requiring treatment, uncontrolled diabetes)
Other
- Using tobacco products, e-cigarettes, vape or other inhaled non-pharmacological substance
- Pregnant, nursing, or intent to become pregnant during study duration
Who the study is looking for
- Symptomatic chronic obstructive pulmonary disease
- History of COPD exacerbation(s)
- Stable medical therapy
- Candidate for bronchoscopy
Age in the registry: 40 years to 80 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.