NCT07363343Recruiting
Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study
Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study (NEPHRON)
Source: ClinicalTrials.gov · Last updated 3 Aug 2026
Brief summary (registry, in English)
To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 3 Dec 2025
- Start date
- 10 Mar 2026
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- The Cleveland Clinic
- Diseases
- High blood pressure
- NCT number
- NCT07363343
What you commit to
- Study type: Interventional
- Planned participants: 200
- From 10 Mar 2026 to the primary completion date, 31 Dec 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Heart block
- Heart rate \<60 or \>120 beats per minute
- Heart failure
- Active connective tissue disease
Lab values
- Creatinine \>1.5 mg/dL
Other
- Taking ≥2 antihypertensive agents during pregnancy
- Renal artery stenosis
- Cerebrovascular accident
- Failed treatment or contraindications to nifedipine, enalapril or labetalol
Who the study is looking for
- Postpartum women aged 18 years or older
- Clinical diagnosis of hypertensive disorder in pregnancy (gestational hypertension, chronic hypertension, preeclampsia with or without severe features)
- Taking Nifedipine 60 mg every 12 hours for blood pressure control
- Persistently elevated blood pressure at/above 140/90 mmHg in a 24-hour time period or have one or more severe range blood pressure at/above 160/110 mmHg requiring a second antihypertensive medication
- English speaking
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.