NCT07364201Completed
A Comparison of Nicardipine and Labetalol for Blood Pressure Control in Intensive Care Patients After Hemorrhagic Stroke Brain Surgery
A Comparison of the Effectiveness of Nicardipine and Labetalol in Controlling Hemodynamics in Postoperative Hemorrhagic Stroke Craniotomy Patients in the Intensive Care Unit
Source: ClinicalTrials.gov · Last updated 23 Jan 2026
Brief summary (registry, in English)
Patients with hemorrhagic stroke who undergo brain surgery (craniotomy) often experience high blood pressure after surgery. Poor blood pressure control can increase the risk of bleeding, brain injury, and other serious complications. In the intensive care unit (ICU), intravenous blood pressure medications are commonly used to keep blood pressure within a safe range. This study aims to compare two commonly used intravenous blood pressure medications, nicardipine and labetalol, in patients who have undergone craniotomy for hemorrhagic stroke. The study will evaluate how well each medication controls blood pressure and heart rate during the first 24 hours of ICU care, as well as the speed at which the target blood pressure is achieved and the occurrence of side effects. Participants will receive either nicardipine or labetalol according to the study protocol. Blood pressure and heart rate will be continuously monitored in the ICU as part of standard care. The results of this study are expected to help health care providers choose the most appropriate medication to achieve stable blood pressure control and improve postoperative care for patients with hemorrhagic stroke.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 30 (actual)
- First submitted
- 15 Jan 2026
- Start date
- 14 Nov 2025
- Primary completion date
- 3 Jan 2026
- Lead sponsor
- Universitas Sumatera Utara
- Diseases
- Stroke, High blood pressure
- NCT number
- NCT07364201
What you commit to
- Study type: Interventional
- Participants enrolled: 30
- From 14 Nov 2025 to the primary completion date, 3 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Known hypersensitivity or contraindication to nicardipine or labetalol.
- Severe bradycardia, advanced atrioventricular block, or uncontrolled heart failure.
- History of bronchial asthma or severe chronic obstructive pulmonary disease.
Other
- Hemodynamic instability requiring vasopressor support at enrollment.
- Pregnancy or breastfeeding.
- Participation in another interventional clinical study during the study period.
Who the study is looking for
- Adult patients (≥18 years old).
- Diagnosed with hemorrhagic stroke.
- Undergoing craniotomy for hemorrhagic stroke.
- Admitted to the intensive care unit after surgery.
- Require intravenous antihypertensive therapy for postoperative blood pressure control.
- Invasive arterial blood pressure monitoring in place.
- Written informed consent obtained from the patient or legally authorized representative.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Adam Malik Hospital, Haji Hospital Medan Coordinator of this site? Confirm its status | Medan | Indonesia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.