NCT07365514RecruitingPhase 1
Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females
Blackcurrants Mitigate Postmenopausal Bone Loss Through Gut Microbiota-Bone Axis: A Randomized Clinical Trial Coupled With a Multi-Omics Approach to Inform Precision Nutrition
Source: ClinicalTrials.gov · Last updated 23 Jul 2026
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate the effects of blackcurrant (BC) supplementation on changes in bone density and gut microbiome composition in postmenopausal females.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 159 (estimated)
- First submitted
- 16 Jan 2026
- Start date
- Jul 2026
- Primary completion date
- Feb 2028
- Lead sponsor
- University of Connecticut
- Diseases
- Osteoporosis
- NCT number
- NCT07365514
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 159
- From Jul 2026 to the primary completion date, Feb 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- taking anabolic agents such as parathyroid hormone or growth hormone, or steroid within 3 months before the start of the study
- those with planned surgery during the study period or within 2 weeks of ending the intervention
Other illness
- history of cardiovascular disease, osteoporosis, metabolic bone disease, cancer, diabetes mellitus, arthritis, or other chronic inflammatory diseases
- taking medications that alter bleeding (such as antiplatelets or anticoagulants) or those with a bleeding disorder
- those with sensitivities or allergies to any of the ingredients for the placebo (rice powder)
Lab values
- taking prescription medications known to alter bone and calcium metabolism
Other
- current smokers
- alcohol consumption exceeding 2 drinks/day (approximately 14g of ethanol per drink) or a total of 12/week
- planning a procedure that includes iodine, barium or nuclear medicine isotopes within the study period
- UConn students and/or employees who any key personnel teach or who report to any key personnel
- study key personnel, partners of key personnel, or dependents/relatives of any key personnel
Who the study is looking for
- postmenopausal (defined as no more than 10 years since final menstrual cycle) females aged 45-70 years
- not on hormone replacement therapy for at least one year before initiation of the study
- maintaining normal exercise level (\< 7 hours/week) and willing to avoid exercise for 24 hours prior to blood and stool sampling
- willing to ingest a dietary blackcurrant supplement or placebo (up to 1,176 mg/day, three 392mg capsules)
- willing to avoid other dietary supplements for the duration of the study
- willing to avoid intake of foods extremely rich in anthocyanins and fermented dairy products containing viable Bifidobacteria or Lactobacilli
- willing to have three blood draws, three stool collections, and three bone scans
Age in the registry: 45 years to 70 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Connecticut, Department of Nutritional Sciences Coordinator of this site? Confirm its status | Storrs | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.