NCT07366242Not yet recruiting
Prognostic Value of (DHODH) Expression in (HGSOC): A Comparative Study Between Neoadjuvant and Adjuvant Chemotherapy Settings
Prognostic Value of Dihydroorotate Dehydrogenase (DHODH) Expression in High-Grade Serous Ovarian Carcinoma: A Comparative Study Between Neoadjuvant and Adjuvant Chemotherapy Settings
Source: ClinicalTrials.gov · Last updated 26 Jan 2026
Brief summary (registry, in English)
* To compare DHODH protein expression in HGSC tissues from patients undergoing Primary Debulking Surgery (PDS - Chemo-naive) versus Interval Debulking Surgery (IDS - Post-NACT). * To evaluate the association between DHODH expression and the degree of chemotherapy response (using the Chemotherapy Response Score - CRS for NACT cases). * To determine the prognostic value of DHODH expression in predicting Platinum-Free Interval (PFI) ,Progression -Free Survival (PFS) and Overall Survival (OS) across both groups.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 72 (estimated)
- First submitted
- 10 Jan 2026
- Start date
- 1 Jun 2026
- Primary completion date
- 1 Jun 2027
- Lead sponsor
- Heba Ahmed Mohamed
- Diseases
- Ovarian cancer
- NCT number
- NCT07366242
What you commit to
- Study type: Observational
- Planned participants: 72
- From 1 Jun 2026 to the primary completion date, 1 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Non-serous histological subtypes
- Low-grade serous carcinoma
- Inadequate tissue for immunohistochemistry
- Missing clinical or follow-up data
Who the study is looking for
- Histologically confirmed high-grade serous ovarian carcinoma
- Availability of adequate FFPE tumor tissue
- Known treatment modality (PDS or IDS)
- Available clinical follow-up including platinum-free interval and survival data
Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Assiut University Coordinator of this site? Confirm its status | Asyut | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.