NCT07366554Not yet recruiting
Epigenetic Factors of Colorectal Adenoma in Korean
Exploration of Epigenetic Factors of Colorectal Adenoma in Korean
Source: ClinicalTrials.gov · Last updated 27 Jan 2026
Brief summary (registry, in English)
This study aims to explore epigenetic factors associated with colorectal adenoma (CRA) in the Korean population. CRA is a key precancerous lesion in the adenoma-carcinoma sequence, and identifying methylated genetic markers may improve early detection and risk stratification for colorectal cancer (CRC). A total of 32 patients undergoing colonoscopic polypectomy will be enrolled. Adenomatous and adjacent normal tissues will be collected for deoxyribonucleic acid (DNA) extraction and bisulfite conversion. Quantitative methylation-specific polymerase chain reaction (qMSP) and Sanger sequencing will be used to assess the methylation status of candidate genes (SFRP2, TFPI2, SEPT9, and SDC2). Stool samples will also be analyzed by whole-genome sequencing (WGS) to evaluate microbiome and genetic profiles. The study seeks to determine whether methylation levels of these genes are significantly elevated in adenoma tissue compared with normal mucosa, thereby identifying potential biomarkers for colorectal neoplasia surveillance and personalized colonoscopy follow-up intervals.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 32 (estimated)
- First submitted
- 14 Nov 2025
- Start date
- 10 Feb 2026
- Primary completion date
- 9 May 2026
- Lead sponsor
- Bundang CHA Hospital
- Diseases
- Colorectal cancer
- NCT number
- NCT07366554
What you commit to
- Study type: Observational
- Planned participants: 32
- From 10 Feb 2026 to the primary completion date, 9 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Inclusion Criteria:
- Adults aged 19-85 years
- Undergoing colonoscopic polypectomy for colorectal adenoma
- Able to understand the study purpose and provide written informed consent
- Adequate tissue available for both adenoma and adjacent normal mucosa sampling
- Exclusion Criteria:
- History of colorectal cancer, inflammatory bowel disease, or hereditary colorectal cancer syndrome (e.g., FAP, Lynch syndrome)
- Previous colorectal surgery that may alter anatomy or pathology
- Inadequate sample quality or failure of DNA extraction
- Refusal or withdrawal of informed consent
- Severe comorbidities that make participation unsuitable at investigator's discretion
Age in the registry: 19 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bundang CHA Hospital Coordinator of this site? Confirm its status | Seongnam-si | South Korea | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.