NCT07366710Active, not recruiting
Measuring Amino Acid and Glucose Metabolism in Healthy Volunteers and NAFLD Patients Using Total-body PET
Quantification of Amino Acid and Glucose Metabolism in Healthy Controls and Patients With Non-alcoholic Fatty Liver Disease Using Total- Body PET
Source: ClinicalTrials.gov · Last updated 2 Feb 2026
Brief summary (registry, in English)
This observational study aims to quantify whole-body amino acid and glucose metabolism in healthy adults and in patients with non-alcoholic fatty liver disease (NAFLD) using total-body PET/CT. The study investigates how orally and intravenously administered PET tracers (18F-FDG and 18F-FET) are absorbed in the gastrointestinal tract, distributed across major organs, and metabolized in different physiological and pathological states. A further objective is to examine how glucagon, during a pancreatic clamp using somatostatin, influences amino acid metabolism in healthy individuals and whether this response is altered in patients with NAFLD. Participants will be healthy volunteers or patients with NAFLD, aged 18-70 years. Depending on study group, participants will undergo one or more total-body PET/CT scans following oral or intravenous tracer administration, and in some cases receive glucagon or placebo infusion. Blood samples will be collected during scanning to assess hormone levels and metabolic responses. Data from these imaging sessions will be used to characterize nutrient metabolism, compare oral and intravenous tracer kinetics, and explore glucagon-induced metabolic changes across study groups.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 36 (estimated)
- First submitted
- 16 Jan 2026
- Start date
- 5 Nov 2024
- Primary completion date
- Oct 2027
- Lead sponsor
- Copenhagen University Hospital, Rigshospitalet
- Diseases
- Fatty liver disease (MASLD/MASH)
- NCT number
- NCT07366710
What you commit to
- Study type: Interventional
- Planned participants: 36
- From 5 Nov 2024 to the primary completion date, Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Diabetes, cancer (active or treated within the last five years) or inflammatory diseases.
- Chronic disorders that require medical treatment
Lab values
- Low albumin
Other
- Pregnancy
- Claustrophobia
- Inability to give consent due to psychological or other causes
- Inability to speak/read Danish
Who the study is looking for
- Age 18-70 years
- Body mass index (BMI) 20-27 kg/m2
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Copenhagen University Hospital, Rigshospitalet Coordinator of this site? Confirm its status | Copenhagen | Denmark | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.