NCT07368205Recruiting
Preoperative Risk Stratification in Endometrial Cancer for Tailoring Lymph Node Staging
Preoperative Risk Stratification in Endometrial Cancer Using Expert Ultrasound and Molecular Classification for Tailoring Lymph Node Staging: Multicentric Prospective Observational Study
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
The goal of this observational study is to evaluaty the accuracy of current risk stratification of patients with endometrial cancer and to redefine lymph node staging recommendations based on real-world clinical data. The main question it aims to answer is: Is there any group of patients who doesn't need lymph node staging for proper indication of adjuvant treatment? Participants are note taking any intervention. They are treated according to current standard of care and followed 3-years after primary surgery.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 350 (estimated)
- First submitted
- 7 Jan 2026
- Start date
- 15 Feb 2026
- Primary completion date
- 29 Feb 2028
- Lead sponsor
- University Hospital Hradec Kralove
- Diseases
- Endometrial cancer
- NCT number
- NCT07368205
What you commit to
- Study type: Observational
- Planned participants: 350
- From 15 Feb 2026 to the primary completion date, 29 Feb 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior oncological treatment within the last five years
Other illness
- Recurrent or metastatic disease at diagnosis
- Cancer synchronous duplicity
Other
- Neoadjuvant treatment
- Inadequate imaging or tissue samples
Who the study is looking for
- Women ≥18 years with newly diagnosed endometrial cancer (any histology)
- Undergoing primary surgical management
- Preoperative expert ultrasound, CT scan (could be waived in low risk cases)
- Preoperatively early-stage (stage I-II) of EC
- SLN mapping attempted intraoperatively
- FFPE tumor tissue available for molecular and IHC testing from biopsy
- Signed informed consent with the participation in the study
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Hradec Kralove Coordinator of this site? Confirm its status | Hradec Králové | Czechia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.