Fact CheckerSign in

NCT07368855Completed

GLP-1 Medicines and Mental Health Changes

Changes in Psychiatric Symptoms, Eating Disorder Behaviors, and Health Behaviors Following Six Months of GLP-1 Treatment for Obesity

Source: ClinicalTrials.gov · Last updated 27 Jan 2026

Brief summary (registry, in English)

Key question: Is the use of GLP-1 weight loss medicines - semaglutide and tirzepatide - associated with improvements in mental health and health-related quality of life? Key finding: Across six- months of GLP-1 treatment, participants reported statistically significant improvements in mental health, eating disorder symptoms, and health-related quality of life domains such as pain interference and sleep quality. Message for readers: Although GLP-1 medicines are prescribed primarily for weight loss and metabolic health benefits, growing evidence suggests that these medicines may also facilitate meaningful improvements in mental health and quality of life.

Status (registry)
Completed
Study type
Interventional
Enrollment
90 (actual)
First submitted
20 Jan 2026
Start date
1 May 2024
Primary completion date
1 Jul 2025
Lead sponsor
University of California, San Diego
Diseases
Obesity
NCT number
NCT07368855

What you commit to

  • Study type: Interventional
  • Participants enrolled: 90
  • From 1 May 2024 to the primary completion date, 1 Jul 2025
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • VASDHS Veterans not receiving GLP-1 medicines for obesity through the weight control clinic

Who the study is looking for

  • Veterans receiving care at the VA San Diego Healthcare System

Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
VA San Diego Healthcare System
Coordinator of this site? Confirm its status
San DiegoUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.