NCT07368855Completed
GLP-1 Medicines and Mental Health Changes
Changes in Psychiatric Symptoms, Eating Disorder Behaviors, and Health Behaviors Following Six Months of GLP-1 Treatment for Obesity
Source: ClinicalTrials.gov · Last updated 27 Jan 2026
Brief summary (registry, in English)
Key question: Is the use of GLP-1 weight loss medicines - semaglutide and tirzepatide - associated with improvements in mental health and health-related quality of life? Key finding: Across six- months of GLP-1 treatment, participants reported statistically significant improvements in mental health, eating disorder symptoms, and health-related quality of life domains such as pain interference and sleep quality. Message for readers: Although GLP-1 medicines are prescribed primarily for weight loss and metabolic health benefits, growing evidence suggests that these medicines may also facilitate meaningful improvements in mental health and quality of life.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 90 (actual)
- First submitted
- 20 Jan 2026
- Start date
- 1 May 2024
- Primary completion date
- 1 Jul 2025
- Lead sponsor
- University of California, San Diego
- Diseases
- Obesity
- NCT number
- NCT07368855
What you commit to
- Study type: Interventional
- Participants enrolled: 90
- From 1 May 2024 to the primary completion date, 1 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- VASDHS Veterans not receiving GLP-1 medicines for obesity through the weight control clinic
Who the study is looking for
- Veterans receiving care at the VA San Diego Healthcare System
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VA San Diego Healthcare System Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.