NCT07369596Recruiting
Impact of Chemotherapy Dose Reductions on Survival Outcomes Among Older NSCLC Patients Without Actionable Mutations
Impact of Chemotherapy Dose Reductions on Survival Outcomes Among Older NSCLC Patients Without Actionable Mutations: A Retrospective Cohort Study.
Source: ClinicalTrials.gov · Last updated 2 Jun 2026
Brief summary (registry, in English)
Evidence suggests that appropriately selected older adults can tolerate standard-dose chemotherapy and achieve survival outcomes comparable to younger patients. However, older adults are usually under-represented in clinical trials and often receive reduced doses of chemotherapy due to concerns regarding age-related frailty, polypharmacy, and toxicity. This study seeks to evaluate chemotherapy dosing patterns and associated survival outcomes in older patients.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 150 (estimated)
- First submitted
- 22 Dec 2025
- Start date
- 1 Jan 2026
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- University of Malaya
- Diseases
- Lung cancer
- NCT number
- NCT07369596
What you commit to
- Study type: Observational
- Planned participants: 150
- From 1 Jan 2026 to the primary completion date, 31 Dec 2026
- 4 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who received targeted therapy or immunotherapy as monotherapy in the first-line setting
Other
- Incomplete survival data
Who the study is looking for
- Age ≥65 years
- Histologically confirmed stage IV NSCLC
- Negative for EGFR mutation, ALK rearrangement, and ROS1 fusion
- Treated with at least ONE cycle of first-line chemotherapy
Age in the registry: 65 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Queen Mary Hospital, The University of Hong Kong Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Recruiting |
| Hospital Wanita Dan Kanak-Kanak Sabah Coordinator of this site? Confirm its status | Kota Kinabalu | Malaysia | Recruiting |
| Universiti Malaya Medical Centre Coordinator of this site? Confirm its status | Kuala Lumpur | Malaysia | Recruiting |
| Hospital Tengku Ampuan Afzan Coordinator of this site? Confirm its status | Kuantan | Malaysia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.